The Phase 2 study is focused on the most difficult of all patients at risk for acute GVHD: those receiving bone marrow transplants from matched unrelated donors
. Because of the inherent differences between unrelated individuals, patients receiving bone marrow transplants from matched unrelated donors
experience an incidence of grades 2-4 acute GVHD in the range of 60% - 70%.
Matched unrelated donor
hematopoietic stem cell transplantation.
It can occur in 30-50% of patients transplanted with either an HLA-matched sibling donor or matched unrelated donor
After being treated with low doses of chemotherapy and radiation, the majority of the patients received a peripheral blood stem cell transplant from a matched unrelated donor
, while the remainder of the group received a transplant from a matched related donor.
"So, statistically the chance of finding a matched unrelated donor
for an Arab patient is virtually zero.
Her aplastic bone marrow had been refractory to treatment and, therefore, she underwent allogeneic stem cell transplantation from a matched unrelated donor
. The first transplant was unsuccessful and the patient remained with bone marrow failure.
Ideally, stem cells from the peripheral blood or bone marrow are sourced from sibling donors or from a matched unrelated donor
if a sibling donor is not available.