While malar rash
and fever were more common in ASLE, no difference was found regarding the other clinical findings.
The cSLE patients were found to present more frequently with malar rash
( P = 0.001; OR , 0.624; 95% CI , 0.470–0.829) but less frequently with arthritis ( P < 0.001; OR , 2.013; 95% CI , 1.512–2.679) and serositis ( P = 0.030; OR , 1.629; 95% CI , 1.053–2.520).
The third flare had occurred one year previously when she presented with a malar rash
and an acute depressive episode of moderate severity, which was exacerbated by treatment with pulsed steroids.
Cutaneou slupus erythematous has been divided into SLE specific and SLE non-specificmanifestations.7,8There is marked variability in the type ranging from malar rash
and discoid lupus to bullae formation,alopecia and vasculitic rashes.9Skin manifestations have a key role in classification of the disease as 4 out of 11 criteria in American College of Rheumatology (ACR) classification criteria are cutaneous.10The main purpose ofthis study was to identify the prevalence and clinical importanceof different skin manifestations in SLE patients in a tertiary care hospital.
Many physicians assume that SLE is a rare condition in Africa--it is therefore seldom considered as a differential diagnosis, except when patients present with classic features, such as malar rash
and swollen painful joints of the hands and feet.
The specific symp-toms of SLE are photosensitivity malar rash
oral ul-cer alopecia serositis etc (D'Cruz et al 2007).
The patients were assessed using the SLE Disease Activity Index 2000 (SLEDAI-2K), which focuses on rash and alopecia; the Systemic Lupus International Collaborating Clinics/ACR Damage Index (SDI), which focuses on alopecia, extensive scarring, and skin ulceration; and the American College of Rheumatology (ACR) revised criteria for SLE, which focuses on discoid rash, malar rash
, and photosensitivity.
For example, psychosis, visual disturbance, cranial nerve disorder, pericarditis, and laboratory markers are assessed by SLEDAI but not by SLAQ, whereas weight loss, fatigue, malar rash
, lymphadenopathy, and photosensitivity are assessed by SLAQ and not by SLEDAI.
-- Nondermatologists often have a dickens of a time differentiating the malar rash
that's a hallmark of systemic lupus erythematosus from butterfly midfacial rashes due to other diseases, most notably rosacea and dermatomyositis.
Over the course of the next 5 years, she developed arthritis, a malar rash
, Raynaud's phenomenon, positive ANA, and dsDNA, and despite treatment with high-dose steroids and several courses of intravenous cyclophosphamide, she developed rapidly progressive nephritis and renal failure.
A malar rash
developed after 12 months of follow-up, while arthritis involving the costochondrial, sacro-iliac and both knee joints occurred simultaneously after 17 months of follow-up.
The symptoms can include arthritis, muscle pain and weakness, fatigue, sun-sensitivity, hair loss, "Butterfly" or malar rash
(a rash across the nose and cheeks), fever, anaemia, headaches, recurrent miscarriages.
* A butterfly-shaped facial rash (malar rash
) that covers the bridge of the nose and the cheeks
In the weeks and month to follow, the malar rash
was followed by pain on inspiration, joint tenderness, tachycardia and palpitations.
I'd have to have some blood work done, he said; the malar rash
is a cardinal symptom of lupus.