1,2) It is characterized by a central maculopapule
with a peripheral ring of scales, specifically notable on the palms and soles.
The BRAF inhibitors are associated with a nonspecific rash consisting of maculopapules
and features similar to those of keratosis pilaris, giving the skin a sandpaperlike appearance.
21) Dermal eruptions were the main manifestation, including maculopapules
, excoriations, and unusual vesicles and ulcers, etc.
Nonpruritic rashes developed in all patients and involved predominantly the trunk and extremities, represented by maculopapules
on 8 patients, papulovesicles on 5 patients, and petechiae on 2 patients (Figure 2, panels B, C).
Cutaneous manifestations of CSS are present in approximately 50% of patients and may be divided into three categories: erythematous maculopapules
, hemorrhagic lesions and cutaneous or subcutaneous nodules.