methotrexate

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Synonyms for methotrexate

toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid

References in periodicals archive ?
Rats (saline (n = 4), MTX (n = 4)) were sacrificed sixty minutes after [[sup.18]F]fluoro-PEG-folate tracer administration [33].
Methotrexate (MTX) is a folic acid analogue and a competitive inhibitor of dihydrofolate reductase (DHFR)3.
fehCG of above 5000 IU had a greater probability of requiring either multiple doses of Mtx or surgery for their ectopic gestation.
LDE-MTX was prepared from a lipid mixture composed of 100 mg cholesteryl oleate, 200 mg egg phosphatidylcholine (Lipoid, Germany), 10 mg triglycerides, 12 mg cholesterol and 60 mg of MTX (5,19).
LCV is reduced form of folic acid; the mechanism behind LCV is that it provides the cofactors which were blocked by MTX. LCV displaces MTX from the intracellular binding sites and actively competes with MTX for transport sites; thereby restores the active folate stores required for DNA/RNA synthesis.
Researchers found lower adherence to sulfasalazine (30 percent) compared to all other DMARDs (40 percent), and speculated that daily therapy with hydroxychloroquine and sulfasalazine, which can require up to six tablets daily, was associated with lower persistence and adherence than once-weekly MTX injections and TNFi once-weekly or less frequent dosages.
As shown in Table 2, MTX + saline group showed a significantly higher levels of ALT, plasma TGF-[beta], plasma MDA, plasma TNF-[alpha], and liver MDA activity compared to the MTX + lactulose group.
Two patients required weekly MTX injection of 50 mg (case 1: 5 times; case 5: 3 times) because of elevated [beta]-hCG levels after the first local treatment (Figures 1 and 2).
FA stimulates the proliferation and differentiation of neural stem cells (NSCs), whereas MTX and VPA impair cell proliferation of embryonic NSCs and amniotic fluid-derived neural stem cells, respectively [19, 20].
Long-term use of MTX leads to accumulation of its intracellular storage form "MTX polyglutamates," which has been suggested as a mechanism for MTX hepatotoxicity [8].
In SELECT-MONOTHERAPY, 68 percent of MTX-IR patients treated with RINVOQ 15 mg achieved ACR20 vs 41 percent treated with continued MTX at week 141
M2 EQUITYBITES-June 18, 2019-MAI Capital Management Acquires MTX Wealth Management to Broaden Geographic Reach