The CL is a heterogeneous tissue consisting of endothelial cells, steroidogenic luteal cells
, as well as fibroblasts, smooth muscle cells, and immune cells.
Genistein was found to inhibit basal and stimulated P4 production by human, rat and bovine granulosa cells as well as porcine theca and luteal cells
(Makarevich et al.
Within a week or so, the luteal cells
stop making progesterone and die.
Insulin-like growth factor-I regulates aromatase activity in human granulosa and granulosa luteal cells
This is a key chemical pathway that affects not only ovulation, but egg cell maturation and granulosa cell differentiation into luteal cells
Similarly, we observed caspase-3 immunoreactivity more frequently in the granulosa cells of the degenerating (atretic) follicles (Figure 2C, b-c) and in the luteal cells
of the corpus luteum (Figure 2C, f-g) in ovaries of the BPA-treated groups compared with controls (Figure 2C, a-e).
In this study, a reduction in the diameter of the corpus luteum in the diabetic + metformin was compared with the other groups Luteal cells
is probably due to decreased lipid reserves because metformin addition to the above-mentioned effects and plasma leptin levels, reduce fat stores [25,26].