A post-authorisation survey to analyse the perioperative teicoplanin plasma concentrations in adult patients with chronic bone sepsis, who received loading doses
of 12 mg/kg 12-hourly for 48 hours followed by 12 mg/kg once daily.
In Figure 1, we simulated the concentrations likely to have resulted from the two loading doses
based on known digoxin population pharmacokinetics (MM-USC-PACK; University of Southern California, www.
In a 6 month multicenter, randomized, double blinded, placebo controlled, phase II study, 170 patients with psoriatic arthritis were treated with abatacept at doses of 3 mg/kg, 10 mg/kg, or 30 mg/kg with loading doses
on days 1 and 15 followed by monthly infusion.
3) In TRITON-TIMI 38, the loading dose
of clopidogrel was delayed relative to the placebo-controlled trials that supported its approval for ACS.
1] min was administered without loading dose
by taking into consideration the fact that hypotension may occur with bolus doses.
Additionally, recent data has demonstrated a reduction in subacute thrombosis in patients receiving a loading dose
of a thienopyridine derivative prior to percutaneous coronary intervention (PCI) (Steinhubl and others 1998).
1) The literature currently favors a two-hour postprandial glucose testing after a loading dose
of 75mg of glucose.
They were first given two doses of reteplase, a drug that breaks up blood clots, and a loading dose
and infusion of abciximab, which prevents platelets from clumping to form new clots.
A loading dose
of a P2Y 12 receptor inhibitor should be given as early as possible or at time of primary PCI to patients with STEMI.
The trial was designed to evaluate isavuconazole at a loading dose
of 200 mg IV every eight hours for the first 48 hours followed by a maintenance dose of 200 mg IV once-daily Day 3 through Day 10 compared to caspofungin at 70 mg IV on Day 1 as a loading dose
and 50 mg IV maintenance dose once-daily Day 2 through Day 10.
A loading dose
is required in serious infections to rapidly achieve therapeutic concentrations.
The letter notes that as long as one understands the difference between the iodine spot test without a loading dose
and the 24-hour iodine loading test, there will be no confusion between "whole-body iodine sufficiency" and "iodine sufficiency.
an IV loading dose
is mandated before starting SC abatacept
The FDA approved generic formulations of both the 75-mg daily dose and the 300-mg loading dose
In a recent pharmacokinetic/ pharmacodynamic study, we found that clopidogrel resistance could be overcome by increasing the loading dose
to 900 mg in [sup.