4) A 18 year old female with LGSIL
on Pap smear can be evaluated with HPV testing to decide if colposcopy is necessary to rule out severe dysplasia.
For example, progression from ASCUS to LGSIL
or one from HGSIL to cervical cancer is treated as a progression.
In conclusion, the present study suggests that the cytotechnologists overdiagnosed cellular changes associated with HPV infection in Pap smears, increasing the FP LGSIL
diagnosis rate at the Manuel Noriega Trigo Hospital.
Reflex HPV testing is not recommended for adolescents with ASC-US and, in general, is also not recommended for LGSIL
. If an HPV test is done anyway, it should not really direct management.
The prevalence of LGSILs
reported in this study is substantially higher than the 1.6 - 2.4% reported in the literature from population-based surveys.
The detection of LGSIL
and high-grade squamous intraepithelial lesions (HGSIL) both increased 207.6% and 104.2%, respectively.
Of these, 75% ASCUS, 19% LGSIL
, and 6% high-grade squamous intraepithelial lesion (HGSIL) (data not shown).
Imiquimod appears to work by enhancing cell-mediated immunity, the process that is also believed responsible for the spontaneous resolution of LGSIL
Among a subgroup of six patients with HGSIL carcinoma in situ during pregnancy, none of the findings progressed in lesion grade, findings from four patients remained carcinoma in situ, and two regressed to LGSIL
The Bethesda System added human papillomavirus (HPV) effect to the diagnosis of mild dysplasia to define low-grade squamous intraepithelial lesion (LGSIL
Tenascin (TN) Expression and Cases Associated With Stromal Inflammation(*) Frank Microinvasive Invasive Diagnosis LGSIL
HGSIL Carcinoma Carcinoma No.
Performing HPV typing on all Pap smears would be unnecessary, he explained, because smear results that are high-grade squamous intraepithelial lesions (HGSIL) require immediate colposcopy, while low-grade squamous intraepithelial lesions (LGSIL
) are likely to regress spontaneously Those LGSIL
that persist for more than a year should be colposcoped.