asparaginase

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Related to L-asparaginase: methotrexate, cyclophosphamide, etoposide, vincristine
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  • noun

Synonyms for asparaginase

antineoplastic drug (trade name Elspar) sometimes used to treat lymphoblastic leukemia

References in periodicals archive ?
G: L-asparaginase treated rats with enoxaparin sodium treated rats and diclofenac sodium treated rats, showed mild vacuolation of epithelial lining pancreatic acini
Maximum L-asparaginase productivity was attained at a temperature of 45C by Bacillus firmus, Streptococcus sp.
A single dose of L-asparaginase (400 IU/kg SQ; 3000 ILF total dose) was administered while the bird was hospitalized, and the bird was discharged with instructions to initiate lomustine (60 mg/[m.sup.2] PO q3wk; 20 mg).
No patient died during the vincristine, daunorubicin, L-asparaginase and dexamethasone (VDLD) induction treatment, and only one patient with appendicitis required treatment in an intensive care unit.
Unfortunately the rapid development of side effects has limited the usage of currently available L-asparaginase. PEG-asparaginase, a form of Escherichia coli L-asparaginase covalently linked to polyethylene glycol, was rationally synthesized to decrease immunogenicity of the enzyme and prolong its half-life [1].
Liver impairment due to L-asparaginase, either in the form of elevated bilirubin levels or in elevated liver enzymes, was significantly higher in pediatrics protocol group.
L-asparaginase has been a mainstay in the treatment of children suffering from ALL, but its use is limited in older and fragile patients due to its toxicity profile.
L-asparaginase (ASNase) is an effective chemotherapeutic routinely administered for canine [6, 7] and feline lymphomas [8-10].
From the available literature, it was evident that if L-asparaginase is given to cancer patients, there would be enormous reduction in L-asparagine level from its pool (4).
Indeed, to screen for caseinase, skimmed milk was used as the carbon source while for esterase, amylase, cellulase L-asparaginase; tween 80, starch, CMC and L-asparagine were used, respectively.
Medications include; Valproic acid and L-asparaginase which are most commonly associated with pancreatitis at therapeutic doses.
Upon further investigation at his follow-up appointment, it was discovered that he had been diagnosed with acute pre-B cell lymphoblastic leukemia (ALL) 2 years earlier and had undergone chemotherapy with cytarabine, vincristine, L-asparaginase, daunorubicin, methotrexate, and glucocorticoids.