PSA

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  • noun

Synonyms for PSA

a protein manufactured exclusively by the prostate gland

References in periodicals archive ?
We subsequently evaluated 9 SNPs from a 24-kbp region encompassing the KLK2 and KLK3 genes (Table 2) for association with concentrations of hK2 and PSA in serum and seminal plasma.
Two recent studies have resequenced KLK3 and neighboring genes from samples obtained from PCa patients and control individuals (12, 13).
6] Human genes: KLK3, kallikrein-related peptidase 3; AR, androgen receptor; CYP17A1, cytochrome P450, family 17, subfamily A, polypeptide 1; CDKN2A, cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); CDH1, cadherin 1, type 1, E-cadherin (epithelial); CD44, CD44 molecule (Indian blood group); MGMT, O-6-methylguanine-DNA methyltransferase; RASSF1A, Ras association (RalGDS/AF-6) domain family member 1; ABCB1, ATP-binding cassette, sub-family B (MDR/TAP), member 1; APC, adenomatous polyposis coli; GSTP1, glutathione S-transferase pi 1; BCL2, B-cell CLL/lymphoma 2; PTEN, phosphatase and tensin homolog.
It is noteworthy that rs2735839 is located near the KLK3 [3] (kallikrein-related peptidase 3) gene on chromosome 19, which encodes PSA, potentially underlying the relationship.
4] Human genes: AR, androgen receptor; PIK3CA, phosphoinositide-3-kinase, catalytic, alpha polypeptide; KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; BRAF, v-raf murine sarcoma viral oncogene homolog B1; KLK3, kallikrein-related peptidase 3; KLK2, kallikrein-related peptidase 2.
The archetypical member of the KLK gene family is the KLK3 gene, which encodes the most widely recognized marker in urologic oncology, prostate-specific antigen (also known as KLK3).
Details on the measurement of mRNAs encoded by CDH16 [6] (cadherin 16, KSP-cadherin), HIF1A [hypoxiainducible factor 1, a subunit (basic helix-loop-helix transcription factor)], HPRT1 (hypoxanthine phosphoribosyltransferase 1), PPIA [peptidylprolyl isomerase A (cyclophilin A)], KLK3 (kallikrein-related peptidase 3; also known as PSA), and TBP (TATA box binding protein) are provided in Supplemental Text 1, Table 2, A and B, and Fig.
Very high concentrations of KLK3 were found in seminal plasma, with relatively low concentrations in urine.
Included in the list of genes are 2 positive controls, KLK3 (kallikrein 3 (prostate specific antigen) and ACPP (acid phosphatase, prostate), 2 prostate biomarkers that are currently used in clinical testing.
the prostate-specific regulation of KLK3 and KLK2) and the different patterns of hormonal regulation in different tissues; e.
In contrast, KLK3, the gene that encodes for PSA, is not up-regulated in cancer (7, 8), and PSA mRNA concentrations may therefore be used to normalize for the amount of prostatespecific RNA in molecular test samples.
Despite the fact that alternative splicing substantially increases the diversity of this locus, most of these putative protein isoforms have not been isolated, with the exception of a few proteins encoded by KLK2 and KLK3 variants (22).
Both genes, KLK2 and KLK3, belong to the human tissue kallikrein gene family, which was recently found to consist of at least 15 members (8).
It was previously reported that the KLK3 (PSA) gene is regulated by steroid hormones (27) and that serum hK3 (PSA) gradually increases with increasing age in healthy males (28).