The prevalence of BK and JC virus
infection is higher in the age range 30-39 years compared to other age ranges.
T-antigen regulates glucose metabolic pathways in brain tumor cells.
 Nonstandard abbreviations: LDTs, laboratory-developed tests; NIBSC, National Institute for Biological Standards and Controls; CMV, cytomegalovirus; EBV, Epstein-Barr virus; BKV, BK virus; JCV, JC virus
; CAP, College of American Pathologists; NIST, National Institute of Standards and Technology; ddPCR, droplet digital PCR; qPCR, quantitative realtime PCR; NSC, normal serum control.
Shah, "Detection of BK virus and JC virus
in urine and brain tissue by the polymerase chain reaction," Journal of Clinical Microbiology, vol.
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease caused by the JC virus
and involves the cerebral white matter.
Atwood, "A combination of low-dose chlorpromazine and neutralizing antibodies inhibits the spread of JC virus
(JCV) in a tissue culture model: implications for prophylactic and therapeutic treatment of progressive multifocal leukencephalopathy," Journal of Neuro Virology, vol.
Yuksek risk altindaki hastalarin klinik orneklerinde BK ve JC virus
DNA pozitifliginin gercek zamanli polimeraz zincir reaksiyonu ile arastirilmasi.
KEY WORDS: BK virus, JC virus
, Polyomavirus, Kidney transplant.
The combination of the clinical presentation, MRI findings, and positive JC virus
PCR results confirmed the diagnosis of PML.
The BK virus and the JC virus
are the polyomaviruses that have been found to cause infections in humans and can contribute to the development of polyomavirus infection in transplant recipients (Costa & Cavallo, 2012).
For example, in January 2012, the FDA updated Tysabri's labeling to indicate that previous exposure to the normally harmless JC virus
increases risk for developing a rare but potentially fatal brain disease called progressive multifocal leukoencephalopathy (PML), which has occurred in people taking Tysabri.
This CSF sample was negative for bacteria by Gram and acid-fast stains, for cryptococcal antigen by latex agglutination, and for cytomegalovirus, BK virus, herpes simplex virus, JC virus
, human herpes virus 6, and varicella-zoster virus by polymerase chain reaction (PCR); however, the sample was not tested for WNV.
Infection by the JC virus
(JCV) is required for the development of PML and patients who are anti-JCV antibody positive have a higher risk of developing PML.
The companies have reportedly applied for an expanded indication to include first-line use for people living with certain relapsing forms of multiple sclerosis (MS) who have tested negative for antibodies to the JC virus
is well known to reside in the urinary tracts, and possibly other organs, of 50-60% of adults, where it generally is asymptomatic, although it may cause a local infection that is not significantly associated with morbidity in immunocompetent individuals [1-4].