After appraisal of all available data on Invirase
(sanquinavir) and the potential risk of cardiac arrhythmias its use leads to, CHMP decided that the benefits of the medicine outweigh its risks, which means that its risk-benefit profile remains positive.
* A new 500-mg tablet of the PI, Invirase
, is now available to be used with ritonavir (Norvir) boosting.
Both people who had the virologic failure were on Kaletra and saquinavir (either Invirase
The company already sells its Viracept and Invirase
drugs at no profit to Sub-Saharan African and in other countries that the United Nations defines as least developed.
The University of Sydney Table 1 Drugs whose metabolism is inhibited and bioavailability increased by grapefruit juice (6,7) Anti-hypertensive Calcium channel blockers FELODPINE ('Agon'; 'felodur'; 'Plendil' NIFEDIPINE ('Adalat'; 'Nyefax') NISOLDIPINE NITRENDIPINE NIMODIPINE ('Nimotop') Certain HMG CoA Reductase inhibitors SIMVASTATIN ('Lipex'; 'Zocor') LOVASTATIN ATORVASTATIN ('Lipitor') Immunomodifiers CYCLOSPORIN ('Neoral') TACROLIMUS ('Prograf') An Anti-convulsant CARBAMAZEPINE ('Tegretol') Certain Benzodiazepine sedatives MIDAZOLAM ('Hypnovel') TRIAZOLAM ('Halcion') Certain Anti-viral agents INDINAVIR ('Crixivan') SAQUINAVIR ('Invirase
'; 'Fortovase') GI Motility stimulant CISAPRIDE ('Prepulsid') An Azopirone Anxiolytic BUSPIRONE ('Buspar') (9)
Pls--Agenerase, Crixivan, Kaletra, Viracept, Norvir, Fortovase, Invirase
It has come to light that patients in some of the nation's correctional facilities are being treated with contraindicated anti-retroviral regimens that include the concurrent use of stavudine with zidovudine; and Invirase
with two nucleoside-analogue-reverse-transcriptase-inhibitors (NRTI).
saquinavir (Fortovase, Invirase
) levodopa (Atamet, Larodopa) Treats Parkinson's Disease.
The FDA approved the first protease inhibitor, Invirase
, in December 1995.
* HIV-I protease inhibitors like indinavir (Crixivan), ritonavir (Norvir), and saquinavir (Invirase
"It is undisputed, that, for at least forty-eight to seventy-two hours, Sullivan was deprived of his medication, although PCDCC [Pierce County Detention and Corrections Center] medical officials knew that Sullivan was in the final stage of AIDS and that he was in dire need of that medication--in particular, his protease inhibitor, Invirase
," wrote judges Stephen Reinhardt, David Thompson, and Thomas Nelson.
(45.) Product insert for Invirase
(saquinavir) [Product Insert].
* Saquinavir mesylate (Fortovase [soft gel capsule], Invirase
[hard gel capsule], SQV), Hoffmann-La Roche