coagulation

(redirected from Intrinsic pathway)
Also found in: Dictionary, Medical, Legal, Encyclopedia.
Related to Intrinsic pathway: Extrinsic pathway
Graphic Thesaurus  🔍
Display ON
Animation ON
Legend
Synonym
Antonym
Related
  • noun

Synonyms for coagulation

References in periodicals archive ?
It exerted a potent antitumor effect toward human leukemia cells through the induction of apoptosis via an intrinsic pathway.
aPTT, a modified version of the activated Partial Thromboplastin Time test, is a test that measures the intrinsic pathway of coagulation.
The intrinsic pathway begins as secretome induces DNA damage, which further results in the activation of ATR and p53 proteins.
Also, fungus polysaccharide extracted from Armillaria mellea revealed a chemopreventive effect on A549 non-small cell lung cancer cells via increment of apoptosis and caspase activation through intrinsic pathway (23)
The present study demonstrates that, dichloromethane fractions of Scrophularia oxysepala induce apoptosis in MCF-7 breast cancer cells in a dose-dependent manner via mitochondrial intrinsic pathway.
The intrinsic pathway is triggered by intracellular stress leading to an incease in mitochondrial outer membrane permeability and release of mitochondrial proteins, including cytochrome C.
There are 2 major types of hemophilia: hemophilia A (classic hemophilia), which is a functional deficiency of Factor VIII of the intrinsic pathway of coagulation; and hemophilia B (Christmas disease), which is a functional deficiency of Factor IX of the extrinsic pathway of coagulation.
Although the intrinsic pathway involves early activation of caspase-9, and the extrinsic pathway is mediated through caspase-8, both lead to activation of the "executioner" caspase-3 and a variety of proteases and endonucleases.
The intrinsic pathway requires only coagulation factors contained in the circulating blood, whereas the extrinsic pathway has extravascular components as well.
The intrinsic pathway is triggered by the contact between blood and tissue factors that occurs when vessels are damaged by conditions such as diabetes, smoking, hypertension, and hypercholesterolemia.
The tissue factor-FVIIa complex provides additional activation of a complex (FIXa-FVIIIa) within the intrinsic pathway.
The mitochondria participated in the process by stimulating the intrinsic pathway via caspase 9 with a reduction in mitochondrial membrane potential (MMP) and an increase in cytochrome c release.
Under the conditions used, TG by the intrinsic pathway in 60-fold diluted human plasma was triggered at 37[degrees]C by adding cephalin in the presence of intact Am-2 and its hydrolysates in solution, and showed inhibition patterns in accordance with the TG parameters (Figure 3 and Table 1).
Leptin attenuates hypoxia/reoxygenation-induced activation of the intrinsic pathway of apoptosis in rat H9c2 cells.