(IL-12) can't be directly administered to patients because it's so powerful that it runs amok in the body, causing side effects like kidney and liver failure, Chiocca explained.
Aberrant regulation of interleukin-12
receptor 2 chain on type 1 cytokine stimulated T lymphocytes in type 1 diabetes.
LPS, Toll-like receptor 4, Immunity index, Peking duck, Tumor necrosis factor -[alpha], Interleukin-12
Captopril and lisinopril supress production of interleukin-12
by human peripheral blood mononuclear cells.
Whole study group Non-AKI group n 226 173 Serum cytokine levels (pg/mL) Interleukin-2 0.1 (0.1-1.6) 0.1 (0.1-1.6) Interleukin-6 7.3 (0.1-30.2) 5.8 (0.1-24.5) Interleukin-10 0.5 (0.1-11.0) 0.4 (0.1-7.5) Interleukin-12
0.1 (0.1-0.1) 0.1 (0.1-0.1) Interleukin-17 2.0 (0.1-16.4) 1.5 (0.1-12.7) Interferon-[gamma] 3.2 (0.1-16.0) 3.2 (0.1-19.2) Tumor necrosis 9.8 (5.4-17.9) 9.3 (5.1-16.6) factor-[alpha] n AKI group p 53 Serum cytokine levels (pg/mL) Interleukin-2 0.1 (0.1-1.4) 0.956 Interleukin-6 12.7 (3.7-53.1) 0.018 Interleukin-10 3.5 (0.1-30.8) 0.068 Interleukin-12
0.1 (0.1-0.1) 0.630 Interleukin-17 4.3 (0.1-20.2) 0.147 Interferon-[gamma] 3.2 (0.1-10.3) 0.764 Tumor necrosis 13.3 (6.2-23.6) 0.040 factor-[alpha] Values are expressed as numbers (portions) and median (interquartile).
(IL-12) is a heterodimeric cytokine which is produced primarily by antigen-presenting cells [14,15].
Tumor Necrosis Factor-[alpha], Interleukin-10 and Interleukin-12
concentrations (pg/mL) in all culture supernatants of PBMCs from patients with CMPA cultivated in the presence of cow's [alpha]-lactalbumin, [beta]-lactoglobulin, caseins, and a protein mixture from whole milk, were significantly higher than in cultures from control subjects (p<0.05) (Figure 1).
Th1 cells produce the proinflammatory cytokine interferon-gamma (IFN-[gamma]) in response to the major Th1-inducing factor interleukin-12
Moreover, there was a decrease in inflammatory processes caused by an increase of the anti-inflammatory cytokine Interleukin-10 and a reduction of the pro-inflammatory cytokine Interleukin-12
after the retreat.
Through an AdV-based vector, Intrexon has already delivered the first clinically validated transcriptional gene switch utilising the RheoSwitch Therapeutic System to regulate the expression and concentration of a powerful cytokine, interleukin-12
, to treat cancer.
Interleukin-10 and interleukin-12
modulation in patients with relapsing-remitting multiple sclerosis on therapy with interferon-beta 1a: differences in responders and non responders.
: a cytokine at the interface of inflammation and immunity," Advances in Immunology, vol.
(IL12) is an important immunoregulatory cytokine that is produced mainly by antigen-presenting cells (APCs).
Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12
Mycobacterial, fungal and other opportunistic infections force the clinician to rule out a large list of conditions associated with secondary immunodeficiency as infectious agents (HIV, Herpesvirus, HTLV), drugs (steroids, immunosuppressants, biologics, chemotherapy), metabolic diseases (diabetes, renal failure, cirrhosis), malignancies (leukemia, lymphomas and solid tumors) and environmental conditions (radiation, heavy metals) (2) but even adult patients can have late onset primary genetic immunodeficiency disorders as chronic granulomatous disease, X-linked agammaglobulinemia, interleukin-12
receptor deficiency or interferongamma (IFN-?) and interleukin-23/interleukin-17 pathway defects (3) explaining their pattern of infection or the presence of opportunistic microorganism.