In the previous antiviral evaluation, we concluded that the immune tolerance
phase roughly corresponds to the minimal phase of liver pathology.
RGMb is expressed in pulmonary macrophages and is thought to be involved with immune tolerance
in the respiratory system.
In our previous study, we demonstrated a significantly prolonged survival in the recipients receiving bone marrow and spleen cells from donor mice tolerant to alloantigens induced by infusion of UVB-iDCs in an allogeneic hematopoietic stem cell transplantation mouse model , suggesting that UVB-iDC-induced immune tolerance
to allogeneic MHC antigens could be long lasting.
PD-1 and CTLA-4 are agents of immune tolerance
, says Khaled Barakat, a physicist who works on drug design at the University of Alberta in Edmonton, Canada.
Although the mechanism underlying this association is not known, one possible explanation is that when a woman carries an embryo that is completely allogenic, it triggers modified immune tolerance
that leads to impaired trophoblast implantation.
The pathogenesis of SLE is complex, which includes loss of immune tolerance
, defective B lymphocyte cells suppression and abnormal T lymphocyte cells immune responses.
That combination was CTLA4-lg, an FDA-approved drug for treating rheumatoid arthritis that suppresses T-cells responsible for immune rejection, and a protein called PD-L1 known to be important for inducing immune tolerance
Immunologists, oncologists, biologists, pathologists, and toxicologists from around the world discuss the principles of basic immunology and cancer immunology, how tumors evade the immune system, various approaches to treat cancer, and how they might be enhanced by inhibiting mechanisms of tumoral immune tolerance
CD28 signaling is a critical pathway required for effector T cell expansion and for regulatory T cells inactivation, and FR104 exerts its immunomodulatory function by blocking CD28 signaling and thereby preventing effector T cells but not regulatory T cells function, thereby promoting immune tolerance
Oral intake of small amounts of glycosylated UC-II presents active epitopes, with the correct three-dimensional structures, to Peyer's patches, which influences the signaling required for the development of immune tolerance
Because of the specialty's interdisciplinary nature, advances in the basic science of immune tolerance
, immunomodulatory therapy, surgical techniques, antimicrobial therapy, pathogen detection, and global surveillance for emerging infections all intersect in this dynamic field.
Immunological data in a preselected subgroup of patients showed that immune tolerance
was achieved, with a reduction in antibodies to components of myelin.
Dietary hapten intake may interfere with oral immune tolerance
mechanisms, while repeated cutaneous exposure to haptens could skew the innate immune system into promoting Th2 responses.
An inflammatory state may arise either due to excessive activation or stimulation of effector cells resulting in a hyperintense proinflammatory state, or if control of immune tolerance
exercised by regulatory cells is insufficient.
and the Immune Tolerance
Network have signed an agreement aimed at developing a diagnostic for type-I diabetes.