Although STAT1 and STAT2 activate IRF1 [7-9, 28], the protein level of IRF1 was not correlated with that of STAT2 in all the tissues and had a significant correlation with that of STAT1 only in the normal tissue of lung adenocarcinoma.
The different correlation profiles of IRF1, eIF2[alpha], ATF4, and PDL1 protein expressions in the normal and tumor tissues of lung cancer, especially adenocarcinoma, may be helpful in selecting conditions for combining ICI and inhibitors against IDO1  or modulators of ER stress.
Concerning genes of the interferon-alpha and -beta pathways, expression of the IFNG, IRF1, and JAK1 genes was significantly lower, while IFNA showed higher expression in dyslipidemic individuals in comparison with G4 and G5 groups (Figure 2).
Furthermore, some genes showed independent negative correlation with physical as well as glycemic and lipid profiles, especially triglycerides (IP10, r = -0.55) and total cholesterol (IFNG, r = -0.54; IRF1, r = -0.49; and JAK1, r = -0.44).
Surace et al., "K63-linked polyubiquitination of transcription factor IRF1
is essential for IL-1-induced production of chemokines CXCL10 and CCL5," Nature Immunology, vol.
Apart from IRF1, IRF-3, IRF-7, and IRF-8, some studies have also briefly explored the role of IRF-5 and IRF-9 in malaria infection.
Itoh, "Cooperative contributions of interferon regulatory factor 1 (IRF1) and IRF8 to interferon-[gamma]-mediated cytotoxic effects on oligodendroglial progenitor cells," Journal of Neuroinflammation, vol.
Li et al., "Complex formation of the interferon (IFN) consensus sequence-binding protein with IRF1
is essential for murine macrophage IFN-[gamma]-induced iNOS gene expression," The Journal of Biological Chemistry, vol.
has been identified as a downstream signaling element of TLR7 in dendritic cell infected with Candida albicans [146,147].