The researchers found that caregivers' average IL-6 concentrations in blood increased at four times the rate observed in noncaregivers.
For now, the new data raise hopes that future treatments designed to reduce excess amounts of IL-6 could prove beneficial for caregiving seniors, says Glaser.
, and PDGF mRNA expression in alveolar cells following stimulation with tobacco-derived antigen.
1a) revealed considerable variation in IL-6 concentrations.
The cortisol concentrations measured in the same serum samples as IL-6 demonstrated a normal diurnal variation, with the peak values at 0530 after a nadir at 0200.
PCR primers for rat glyceraldehyde-3-phosphate dehydrogenase (G3PDH), IL-1, IL-6, TNF-[Alpha], IL-2, and IFN-[Gamma] were purchased commercially from Clontech (Palo Alto, CA); PCR primers for rat IL-4 and IL-5 were synthesized by the core facility of the Human Studies Division at the U.
The secretion of IL-1[Beta] and IL-6 was undetectable in both serum and BAL fluid in all animals (data not shown).
In fact, the Expert Committee on Biological Standardization of the World Health Organization recently adopted the Ares-Serono Glycosylated form of IL-6
as the international standard.
levels were measured daily in samples of nasal secretions.
Treatment with Ceplene and IL-2 also resulted in a decrease in the production of IL-6
, a pro-inflammatory cytokine associated with the down-regulation of T cells and NK cells.
These include Traps for IL-1, IL-4, and IL-6
, a single dual Trap which blocks both IL-4 and IL-13, as well as a Trap for vascular endothelial growth factor (VEGF Trap).
This family includes Cytokine Traps for IL-1, IL-4, and IL-6
, and a single Trap which blocks both IL-4 and IL-13.
) antagonist, which utilizes IL-6