Moreover, if i = j in ([p.sub.i], [p.sub.j]) we are talking of homodimer
and otherwise of heterodimer.
Each monomer of the homodimer
contains six structural domains with discrete functions.
They can form homodimers
or heterodimers and are closely interrelated.
The retropepsin molecule has only one lobe, which consists of only one aspartic residue, and the activity requires the formation of a noncovalent homodimer
Immunolabelling experiments suggest that S100A8 and S100A9 are largely present in AML cells as homodimers
or oligomers as an antibody specifically detecting S100A8/S100A9 heterodimer detected very few positive cells.
Caption: Figure 1: Overview of structures of homodimer
Roddis et al., "HLA-B27 heavy chain homodimers
are expressed in HLA-B27 transgenic rodent models of spondyloarthritis and are ligands for paired Ig-like receptors," Journal of Immunology, vol.
Peripheral DP T cells have been defined as an extrathymic population , which is supported by results presented herein: peripheral DP T cells expressed a CD8aa homodimer
but did not express CD1b molecules on their surface (Supplemental Figure 1).
Thakker, "SEDLIN forms homodimers
: characterisation of SEDLIN mutations and their interactions with transcription factors MBP1, PITX1 and SF1," PloS one, vol.
(1) The c molecules that penetrate the cell membrane form homodimers
cc on the membrane.
(1999) obtained a crystal of this protein, formed by a tetramer from two homodimers
due to its crystallographic symmetry, and identified 17 amino acids involved in the interactions that facilitate the formation of the tetramer, thus achieving greater stability: [Cys.sub.109], [Glu.sub.114], [Thr.sub.116], [Gly.sub.118], [Ala.sub.121], [Leu.sub.123]-[Leu.sub.124], [Tyr.sub.127]-[Asn.sub.128], [Asn.sub.131], [Lys.sub.163], [Glu.sub.166], [Tyr.sub.171], [Arg.sub.447], [Pro.sub.450]- [Ile.sub.451], [Cys.sub.453] (Figure 3).
Phosphorylated STAT3 (pSTAT3) and pSTAT1 form homodimers
or heterodimers via phosphotyrosyl peptide interaction of their SH2 (Src homology 2) domains, resulting in translocation to the nucleus, binding to DNA at the consensus binding sequence TTCC[C/G]GGAA, and transcription of target genes .
In general, homodimers
of sMafs lacking TAD (i.e., MafG:MafK) repress gene transcription by binding to the Maf recognition element (MARE: TGCTGACT CAGCA) [6, 12].
Later on, it is converted into the pre-prohormone and this forms the homodimers
. The homodimer
, or the mature hormone, then undergoes glycosylation and produces two identical 70-kDa monomer subunits.
These phosphorylated STATs then form homodimers
or heterodimers and translocates into nucleus11.