Some studies have revealed that cholesterol-induced LPL gene expression in the liver is directly regulated by RXR/LXR heterodimers
in a tissue-specific manner, which is mediated predominantly by LXR[alpha] in vivo (Zhang et al.
39] Recently, HIF-2[alpha] targeted antagonist, PT2399 is shown to impart antitumor activity in human renal cell carcinoma cell lines, and xenografts with higher expression of HIF-2[alpha] by dissociating HIF-2[alpha]/HIF-1[beta] heterodimer
with decreased HIF-2[alpha] targeted genes.
Decreased Bmal1 may result in less formation of CLOCK-BMAL1 heterodimers
, which regulated the clock-controlled gene expression through E-Box.
This antibody detected the E1-E2 heterodimer
of LV (75 kDa) as well as the E2 monomer (50 kDa) in Western blot analysis, although the reactivity against BVDV-1 E2 was much stronger (Figure 2, panel A).
The dephosphorylated Bad forms a heterodimer
with Bcl-2 and Bcl-xl, inhibiting the anti-apoptotic functions of the proteins and allowing Bax to trigger mitochondrial depolarization (Masters et al.
PPAR[gamma] forms a heterodimer
complex with one of the three retinoid X receptor (RXR) proteins and then binds to PPAR-responsive elements (PPRE) in promoters of PPAR[gamma] target genes (Mangelsdorf and Evans, 1995; Schulman et al.
HIF1 is a heterodimer
consisting of oxygen dependent transcriptional factors HIF1A and ARNT, or HIF1B.
8) BMPs are active both as homodimer molecules that consist of two identical chains, and as a heterodimers
consisting of two different chains.
As a general rule, ligand binding promotes the formation of homo and heterodimers
between different receptors, which leads to the activation of the cytoplasmic domain kinase activity, resulting in transphosphorylation of the latter in tyrosine residues .
6) By contrast, in APL the PML-RARA fusion protein forms heterodimers
with wild-type PML and prevents formation of these domains.
NF-[kappa]B proteins comprise members of the Rel/NF-[kappa]B family, forming homo- and heterodimers
through a combination of the p65 (or RelA), p50, p52, c-Rel, or RelB subunits.
About 90-95% of CD patients express HLA-DQ2 molecules (heterodimers
) on the surface of specific antigen-presenting cells in the small intestine, and the remaining 5-10% express the HLA-DQ8 heterodimer
GPI--A dimeric enzyme encoded by two loci GpiA and Gpi-B expressed in all tissues, with the presence of heterodimers
The findings showed the precise structure of the virus-like particle bound to a key part of the antibodies, called the antigen binding fragment, or Fab, which attaches to the heterodimers
making up the virus's outer shell.
59) The sequence alignments of the core heterodimers
of some [NiFe]-hydrogenases (Fig.