Insulin-like growth factor-I receptor/human epidermal growth factor receptor heterodimerization
contributes to trastuzumab resistance of breast cancer cells.
Activation by TCDD causes receptor translocation to the nucleus, dissociation from its cytosolic chaperones, and heterodimerization
with its AHR nuclear translocator (ARNT) partner, also a member of the bHLH/PAS superfamily (Reyes et al.
of Msx and Dlx homeoproteins results in functional antagonism.
of the Drosophila ecdysone receptor with retinoid X receptor and ultraspir acle.
Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): heterodimerization
with ARNT is not necessary for nuclear accumulation of HIF-1alpha.
Insulin-like growth factor-1 receptor/epidermal growth factor receptor (EGFR) heterodimerization
and resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer.
Numerous aspects of integrin biology--including expression, heterodimerization
, ligand binding, and downstream signaling--are modulated by glycosylation (63).
G-protein-coupled receptor heterodimerization
modulates receptor function.
Evidence for two autonomous transactivation functions (AF-1 and AF-2) and heterodimerization
3] to the nuclear vitamin D receptor (VDR), heterodimerization
with a retinoid X receptor (RXR), and interaction with specific vitamin D-responsive element (VDRE) consensus sequences of target genes (Colnot et al.
The homo- and heterodimerization
of PCD-related oncogenes confer a survival advantage to evolving neoplastic cells, allowing alterations in additional oncogenes for cancer development.
Four N-terminal zinc-fingers mediate sequence-specific DNA-binding, while two C-terminal zinc-fingers mediate homodimerization and heterodimerization
within the family.
In vitro reconstitution of the photosystem I light-harvesting complex LHCI-730: Heterodimerization
is required for antenna pigment organization.
To illustrate the practice of this invention, we have induced: (1) the intracellular aggregation of the cytoplasmic tail of the zeta chain of the T cell receptor (TCR)CD3 complex thereby leading to signaling and transcription of a reporter gene, (2) the homodimerization of the cytoplasmic tail of the Fas receptor thereby leading to cell-specific apoptosis (programmed cell death) and (3) the heterodimerization
of a DNA-binding domain (Gal4) and a transcription-activation domain (VP16)
Ovine placental lactogen-induced heterodimerization
of ovine growth hormone and prolactin receptors in living cells (Biener et al.