IL-27, a heterodimeric
cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells.
Adipocytespecific transcription factor ARF6 is a heterodimeric
complex of two nuclear hormone receptors, PPARy and RXRa.
Integrins are heterodimeric
(ap) cell receptors containing an extracellular and a transmembrane domain, as well as a short cytoplasmic tail in each subunit.
IL-23, a member of the IL-12 cytokine family, is a heterodimeric
protein with the ability to support the polarization and expansion of T cells toward a Th17 phenotype [16,17].
Activated PPAR[gamma] shapes a heterodimeric
complex with retinoid X receptor (RXR) and binds to peroxisome proliferator hormone response elements, upregulating specific target genes and downregulating others .
Sodium orthovanadate exposure (a) enhanced inducible forms of CREB (cAMP response element-binding protein) in both resting and antigen-stimulated T cells, followed by activation of the p50/p65 heterodimeric
form of NF-[kappa]B, and (b) inhibited activation of NFAT (nuclear factor of activated T cells) and affected levels of its constitutive DNA-binding activity in resting lymph node T cells, whereas it enhanced AP-1 activity in transgenic mouse C[D.
The closely related homomeric and heterodimeric
mannose-binding lectins from garlic are encoded by one-domain and two-domain lectin genes, respectively.
is a heterodimeric
glycoprotein produced primarily in the placenta and has multiple endocrine, paracrine and immunoregulatory actions.
In the signal transduction pathway of 20E, 20E initially binds to its receptor, a heterodimeric
transcription complex including ecdysteroid receptor (ECR) and ultraspiracle protein (USP) (Lan et al.
RUNX proteins form a heterodimeric
complex with core-binding factor subunit b (CBFb), which increases DNA binding capability and stabilizes the complex.
Structurally, PSII reveals the transmembrane reaction core consisting of the heterodimeric
D1/D2 proteins, which are centrally involved in binding the photo-oxidizable [P.
JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy.
This collaboration marks the first time we have used our new XmAb bispecifics technology, which consists of stable and easily expressed heterodimeric
Fc domains that allow us to build robust molecules in a variety of formats that preserve many beneficial features of antibodies.
A novel heterodimeric
cytokine consisting of IL-17 and IL-17F regulates inflammatory responses.
Previous results have shown that RUNX1 protein is a heterodimeric
transcription factor that binds to the core element of many enhancers and promoters.