The rate of recurrence is low in patients with genital HSV-1 and often high in patients with genital HSV-2 infection
. The median number of recurrences is 1 in the first year of genital HSV-1 infection, and many patients will not have any recurrences following the first year.
"The greater cofactor effect for incident HSV-2 infection
than for prevalent HSV-2 infection
might be because newly acquired HSV-2 infection
is associated with an increased frequency and severity of genital ulceration, viral shedding, and inflammation in the genital tract, symptoms and manifestations that decrease with time after infection," according to Katharine J.
In conclusion, a patient with HIV infection presented with genital pseudotumor formation associated with HSV-1 and HSV-2 infection
. The pseudotumors did not respond to treatment with acyclovir and foscarnet but showed near complete resolution with leflunomide, an agent with antiviral and immunosuppressant properties.
Conclusion: The findings in this study confirmed the presence of HSV-2 infection
in Zaria metropolis, Kaduna state with seroprevalence comparable to rates reported in various towns and cities in Nigeria and other countries of the world.
increases the risk of HIV infection due to mucosal disruption caused by genital ulcers, which are an entryway for HIV (4).
[1-3] Periodic symptomatic reactivation and asymptomatic viral shedding are characteristics of HSV-2 infection
. HSV-2 is a long lasting infection; the virus becomes permanently latent in the nerve root ganglia corresponding to the site of inoculation (the trigeminal ganglia for orolabial infection and the sacral ganglia for genital infection).
* protected mice against HSV-2 infection
when applied vaginally or anally/rectally just before a high dose of virus
The other problem with HSV-2 infection
in adolescents is that it is somewhat difficult to determine given that many infections are asymptomatic or go unrecognised; hence it differs with most of other STIs in general.
This suggests that South African women may also be at risk of HSV-2 infection
Living with symptomatic HSV-2 infection
can result in several psychological concerns including fear of transmission to others, anxiety about possible long-term consequences for general health, difficulties with intimacy and spontaneity, and feelings of undesirability (Green & Kocsis, 1997; Luby & Klinge, 1985).
is one of the most common sexually transmitted infections in the world.
Previous research has established that a synergistic relationship exists between HSV-2 infection
and HIV transmission and acquisition, and that populations with high l-ISV-2 prevalence often have high rates of HIV infection.
An investigational vaccine had some efficacy in preventing genital herpes simplex virus type 1 infection and disease, but none in preventing HSV-2 infection
or disease in an industry-sponsored field trial
The study enrolled 8,323 women between ages 18 and 30 who did not have HSV-1 or HSV-2 infection
at the start of the study.
(5) Genital HSV-2 infection
increases the likelihood of HIV acquisition and transmission (2,6) and interventions to prevent or treat HSV-2 infection
have the potential to reduce the population transmission of HIV.