References in periodicals archive ?
HLA frequencies in Pakistani population in comparison with Caucasian, oriental and negroid population.
3] The results obtained for HLA class II polymorphisms in RA patients in Federation of Bosnia and Herzegovina (FB&H) point to the role of allelic groups DRB1*01 (OR=2.
Clinical utility of celiac disease-associated HLA testing.
However, NGS has its limitations: turnaround time is in the range of days by NGS, whereas SSP, quantitative polymerase chain reaction, or even reverse SSO can generate data in a matter of hours; instrumentation costs are high; and it is difficult to determine the clinical significance of newly discovered HLA alleles because of polymorphisms outside the antigen-recognition site.
During this exchange, the exhaust valve motion is temporarily overridden by the brake cam lobe, leaving the HLA temporarily unloaded during breaking events (Figure: 3a).
With the advent and growing implementation of routine HLA genotyping by NGS within clinical immunogenetics laboratories, the pace of discovery and annotation of novel HLA alleles continues to grow.
Several studies have been performed in order to determine the HLA polymorphisms in different populations and ethnic groups; showing a wide variability across them (10, 11).
Exons 2 and 3 for class I and exon 2 for class II are routinely sequenced because they constitute the peptide-binding region of the corresponding HLA molecules.
Wikstrom, "Improved flow cytometry based cytotoxicity and binding assay for clinical antibody HLA crossmatching," Human Immunology, vol.
M2 PHARMA-October 20, 2014-Affymetrix exclusively licenses technology from Peptide Groove enabling HLA typing from genotyping data