In utero and lactational exposure to low-dose genistein-vinclozolin mixture affects the development and
growth factor mRNA expression of the submandibular salivary gland in immature female rats.
Growth factors are a special class of proteins that can aid in tissue repair and regeneration.
The study, published in ACS Applied Materials and Interfaces, sees Gaharwar's lab designing two-dimensional (2D) mineral nanoparticles to deliver
growth factors for a prolonged duration to overcome this drawback.
Through Histogen's patented technology process, fibroblast cells are induced to become multipotent stem cells, and there is upregulation of
growth factors which have been shown to be important in hair viability.
While the rats in the stressed control group experienced a decrease in the
growth factors needed to repair the ulcers, those in the tocotrienols group increased their levels.
TABLE 2: OVERVIEW OF STUDIES OF IMPLANTS CARRYING
GROWTH FACTORSIan Rand, Business Barclays' SME
Growth Factors Index measures the strength of 12 key '
growth factors' essential to business productivity.
It has a series of small ducts (eight-twenty) known as ducts of Rivinus opening along the sublingual folds1,2 and a large duct known as Bartholin's duct opening along with submandibular duct.3,4 Histologically, sublingual gland is a mixed mucous gland with mucous acini capped with serous demilunes.3 Salivary glands in addition to production of saliva are also associated with production of various
growth factors such as transforming growth factor-alpha (TGF-[alpha]), epidermal
growth factor (EGF), hepatic
growth factor (HGF) and Nerve
growth factor (NGF)4 and secretion of peptides, proteases, amylase, renin, nerve
growth factor, kallikreins and glucagon.5,6
Results indicated that the MSCbFGF led to an increased production of
growth factors that, in turn, accelerated fracture repair by stimulating blood vessel growth and differentiation of both endogenous and exogenous MSCs into osteoblasts, which are the cells that form new bone.
By activating signaling pathways,
growth factors increase cellular and extracellular activity to nourish, rebuild, and remodel the extracellular matrix--the structural framework responsible for skin cohesion, firmness, and elasticity.
Fibroblast
Growth Factors: Biology and Clinical Application: FGF Biology and Therapeutics
Furthermore, platelets have been identified as producers of high quantity of
growth factors, such as Platelet Derived
Growth Factor (PDGF), Transforming Growth Factor-B1(TGF), TGF-B2, Fibroblast
Growth Factor (FGF), Vascular Endothelial
Growth Factor (VEGF), Insulin-like
Growth Factor (IGF) that stimulate cellular proliferation, matrix remodeling and neo-angiogenesis (Dohan Ehrenfest et al., 2010; Farina et al., 2013).
Developed by biomedical engineers at the University of Glasgow, the technique can help stimulate "
growth factors" - molecules that help the body to regenerate.
Researchers from the university's Institute of Molecular Cell and Systems Biology and School of Engineering found a unique property of the polymer poly(ethyl acrylate) allows
growth factors to be effective at doses around 300 times lower than currently possible, reducing the risk of side-effects and the potential cost of treatment.
Fibroblast
growth factors and their receptors in the central nervous system.
