By activating signaling pathways, growth factors
increase cellular and extracellular activity to nourish, rebuild, and remodel the extracellular matrix--the structural framework responsible for skin cohesion, firmness, and elasticity.
However, these recombinant growth factors
can be extremely expensive and, perhaps more importantly, lack sufficient biological activity.
This suggests that MANF spreads more readily in brain tissue than other known growth factors
TNS Recovery Complex, manufactured by Skin Medica, contains growth factors
produced by fibroblast cells, which also make collagen and hyaluronic acid.
Sometimes androgen receptors are bypassed completely, and cell growth is activated by other naturally occurring compounds including insulin-like growth factor
-1, epidermal growth factor
, and others.
Following the formation of these bodies, the cell population was enriched with specific growth factors
to form progenitor cells that expressed genes indicative of the developing inner ear.
Tissue engineers can selectively place different growth factors
in different parts of a polymer scaffold, for example, to push a population of stem cells to form multiple layers of different tissue types.
Gastrin also stimulates the secretion and expression of other important growth factors
and receptors within and on the surfaces of the cancer cells involved in tumor growth.
We conducted a leg ulcer study with fibroblast growth factors
last year, applying them directly into the ulcers.
Angiogenic growth factors
in the pathology of a murine model of acute lung injury.
In some cases, angiogenic growth factors
--such as endothelial growth factor
, tissue growth factors
alpha and particularly beta, vascular endothelial growth factor
, and prostaglandin-derived growth factor
--incite capillary budding, vascular hyperpermeability, and fibroblast recruitment.
Chiron Corporation (Emeryville, CA) has patented purified compounds comprising truncated insulin-like growth factor
binding protein capable of binding to an antibody specific for the compound or to an insulin-like growth factor
wherein the truncated insulin-like growth factor
binding protein has a decreased affinity for insulin-like growth factors
The BST-GEL family of gels is an attractive technology in the delivery of growth factors
and genes to accelerate the repair of fresh bone fractures.
But developing an efficient and economical way to administer those chemicals -called growth factors
-- in low, sustained doses proved difficult.