Histomorphometric analysis of the epiphyseal growth plate
in rats after prenatal alcohol exposure.
Lower ends of femurs were separated for evaluation of growth plate
In addition to its growth promoting effect on bone through increases in GH secretion, T itself also contributes to bone formation and the pubertal growth spurt, perhaps through a direct interaction with growth plate
chondrocytes (Nilsson et al.
The CT scan described the humeral head growth plate
as irregular, possessing both fused and unfused regions with metaphyseal and the epiphyseal overgrowth and remodeling.
Although infections with Staphylococcus species are occasional causes of vertebral osteomyelitis in juvenile poultry with active growth plates
, it is only sporadically reported in raptors and companion birds.
The study concluded by suggesting that sleeping and bone length growth are related temporarily, which again supports the notion that certain behavioural states in a child could exacerbate the discomfort and pain experienced by having increased hormone output adding to the cellular forces exerted across the epiphyseal growth plate
Premature closure of the epiphysis secondary to infection rather than direct injury to the growth plate
was excluded (Engber and Clancy, 1978).
After noticing that pluripotent mESCs tend to stick together in round colonies while cells on the colony edges in contact with the rigid growth plate
tend to differentiate more quickly, the team decided to focus on mESC mechanics rather than chemistry.
On the other hand, the problem of the evolution of the growth plate
at the end of long bones is identified as a critical problem in mechanobiology (cf.
The parameters measured included thickness of the joint cartilage, thickness of the whole epiphyseal growth plate
and its three zones.
Furthermore, growth was markedly improved as were the growth plate
abnormalities and features of osteomalacia.
A 2008 study with genetically engineered mice without VDRs reported, as expected, that the mice developed a bone and growth plate
phenotype similar to humans with severe vitamin D deficiency.
GH is also advocated for managing short stature in children with proven GH deficiency, where there is expected benefit based on age at presentation and growth plate
Caine D, Roy S, Singer KM, et al: Stress changes of the distal radial growth plate
As a result, children often suffer fractures of the growth plate
in the setting of trauma.