Although various clinical studies confirmed the safety and feasibility of G-CSF
in AMI as the authors suggested, sporadic cases of AMI were reported in cancer patients, in healthy subjects and in patients with severe coronary artery disease receiving G-CSF
Further studies are under way to elucidate the intracellular pathways mediating this enhanced proliferation, to identify the specific factors that make Apollo's hcx(TM) G-CSF
and SCF so unique in mediating stem cell proliferation and differentiation," Dr Russell-Jones added.
They believe this approach would be useful in guiding primary G-CSF
prophylaxis in breast cancer patients.
Increased expression of G-CSF
/G-CSFR in neurons subjected to hypoxia supports evidence that G-CSF
has a protective signaling mechanism in response to neural damage.
In the cancer study, stem cells mobilized by Imprime PGG plus G-CSF
will be harvested, reintroduced into patients following their chemotherapy, and reconstitution of their immune system monitored.
, myocardial infarction, stem cells OZET
This strategic agreement with PLIVA will further our efforts to be a leader in this emerging marketplace, and we are confident that we bring together considerable expertise that will result in the successful introduction of G-CSF
and future generic biopharmaceuticals.
The competition is fierce in China with about 20 G-CSF
products already in the market.
With genotype 2 and genotype 3 patients, we would need to treat 13 with erythropoietin or 54 with G-CSF
to obtain 1 additional SVR, when compared with dosage reductions of ribavirin or pegylated interferon, respectively.
In a study aimed at determining if interleukin 8 and G-CSF
held the same predictive value, Dr.
Biotechnology, companies now can manufacture human GM-CSF and G-CSF
in yeast or bacteria, and researchers have begun testing the usefulness of these two recombinant growth factors in various medical conditions, including AIDS (SN: 9/12/87, p.
5 [micro]g/kg was given subcutaneously, for 5 days/month for 3, 6 and 12 months.
Other research has shown G-CSF
having a beneficial impact on left ventricle ejection fraction, a measurement of how powerfully the heart is pumping oxygenated blood back into the aorta and the rest of the body with each beat.
Aaron Havens of the University of Michigan, involved isolating G-CSF
mobilized VSEL stem cells from the blood of healthy donors and transplanting them into burr holes made in the cranial bones of SCID mice.