(7.) Many drug manufacturers admit in product labels that they do not know how the drugs work--take, for example, the labels as shown in the Physicans' Desk Reference (Thomson 2007) for the following widely used drugs: Ativan, Effexor, Fluothane
, Inderal, Lodine, Neurontin, and Risperdal.
These included Terylene, the first polyester fibre; MDI, a key element of poly-urethane foam, and fluothane
, which in 1953 superseded chloroform and ether to become the most commonly used anaesthetic in the world.
The day after, rats were anesthetized with 4% halothane (Fluothane
, Zeneca, Porrino, Pontevedra, Spain) in a mixture of 70% [N.sub.2]O and 30% [O.sub.2] by means of endotracheal intubation and assisted ventilation (Harvard Apparatus, 683 rodent ventilator, Holliston, Massachusetts, USA).
All animals were killed 24 hr after the last dose by an overdose of fluothane
followed by cervical dislocation.
The products range consists of Tenormin, Inderal, Zestril and Etizem (cardiovascular; Nolvadex and Zoladex (anti-cancer), Fluothane
and Diprivan (anaesthesia); Hibiscrub and Hibicet (antiseptics); Proxen and Synflex (NSAIDs) and Meronem (antibiotic).
The pharmacokinetics of halothane (fluothane