The unregulated up-take of these circulating oxLDLs into the arterial intima by CD36 altered cytoskeletal dynamics to induce macrophage trapping in arterial intima which might cause foam cells formation leading in to fatty streaks
, the hallmark of atherosclerosis lesion (Park et al.
As foam cells coalesce, they form fatty streaks
and, ultimately, atheromatous plaque.
There is a widespread consensus that the more fatty streaks
you have, and the thicker they get, the more likely they are to go on to fibrous plaques," says McGill.
A macroscopically 'normal' aorta was defined as one in which the intimal surface of the vessel was smooth, glossy and of uniform colour, with no fatty streaks
or other lesions.
Supporting sex determination of atherosclerotic CVD, the Pathological Determinants of Atherosclerosis in Youth study found more extensive fatty streaks
in the right coronary arteries and thoracic aortas of men, but greater abdominal aortic disease in women (82).
Claudio Napoli and colleagues showed in a previous study that fatty streaks
, the earliest lesions of atherosclerosis, have already formed in fetal arteries.
The first phase in the development of CAD is considered to be the infiltration of native LDL into the intima of coronary vessels, where it is oxidized and taken up by monocytes to form foam cells and fatty streaks
Inflammation, which is implicated in the formation of early fatty streaks
as well as at the onset of adverse cardiovascular events, causes cells within the plaque to secrete enzymes that degrade and weaken the fibrous cap, leading to rupture of unstable plaques and thrombus (clot) formation.
Page 389: Wherever they saw fatty streaks
(an early state of atherosclerosis), they also found a deficiency in EFAs (Parent Essential Oil's LA).
Oryzanol decreases cholesterol absorption and aortic fatty streaks
Classification of lesions was done on gross examination, according to scoring criteria14: 0=Nil lesion, 1=One to two fatty streaks
, 2=Three to five fatty streaks
, 3 = More than five fatty streaks
, 4=Atheromatous plaque.
Hamsters develop fatty streaks
in the walls of their arteries in a similar way to humans, which is a sign of heart disease.
Blackwhite differences in aortic fatty streaks
in adolescence and early childhood: the Bogalusa Heart Study.
However, 25 of the 32 showed regions with fatty streaks
, the beginnings of atherosclerosis, and 19 of the 32 had areas with hardened plaque.
Foam cells represent the very beginnings of the fatty streaks
that can arise in blood vessels as early as adolescence and can lead to full-fledged atherosclerotic plaque later in life (SN: 1/20/90, p.