Private practice: Julie Malan, Registered Genetic Counsellor, tel: 082 553 5891 Familial Cancer
Clinic at Femina Hospital, tel: 021 328 2676
syndromes, including breast/ovarian and colon cancers, are perhaps the most recognized example of this.
Melanoma and breast cancer are fairly common bedfellows in familial cancer
syndromes, and both types of cancer have been linked with mutations in cyclin-dependent kinase inhibitor 2A, a tumor suppressor gene, in some studies of familial cancer
In the past, physicians had to rely on a family history that suggested a risk of this familial cancer
Researchers examined the 16INK4A gene because of its suspected role in the progression of retinoblastoma and its involvement in a predisposition to familial cancer
Jennifer Ibrahim, MD - clinical geneticist specializing in preconception genetics as well as familial cancer
For example, if a patient's grandmother had breast cancer when she was 65, an aunt had cervical cancer at age 25, and an uncle had lung cancer because he smoked, that may indeed be a strong family history of cancer, but when you ask if this is consistent with a familial cancer
syndrome, it is not," Dr.
We're not suggesting that every familial cancer
syndrome involves p53," he says.
Young-onset cancer is a hallmark of many familial cancer
syndromes, but it was not clear whether family members of young-onset familial pancreatic cancer patients were at greater risk than family members of older-onset patients.
For patients at higher risk due to personal or familial cancer
history, the ACS recommends screening colonoscopies as often as every three years.
Screening should be conducted at a place with expertise in an effort to minimize false-positive results, which often lead to biopsy," said Dr Claudine Isaacs, an associate professor of medicine and co-director of the Fisher Centre for Familial Cancer
Research, Lombardi Comprehensive Cancer Centre at Georgetown University.
Professor Jacobs' clinical activities and expertise include the surgical management of gynecological cancer, management of familial cancer
and screening for ovarian and cervical cancer.
Both physicians encourage women who carry BRCA1 or BRCA2 mutations to enroll in clinical research trials aimed at improving strategies for prevention, surveillance, and treatment of women with familial cancer