Should children at risk for familial adenomatous polyposis
be screened for hepatoblastoma and children with apparently sporadic hepatoblastoma be screened for APC germline mutations?
Familial adenomatous polyposis
associated thyroid carcinoma: a distinct type of follicular cell neoplasm.
Large submicroscopic genomic APC deletions are a common cause of typical familial adenomatous polyposis
Brendon, 38, and his sons have familial adenomatous polyposis
Last year the HFEA issued a licence to University College London to screen embryos for the gene that causes familial adenomatous polyposis
- a type of cancer.
Frequency and parental origin of de novo APC mutations in familial adenomatous polyposis
Familial Adenomatous Polyposis
(FAP) is a rare, inherited disorder in which people affected develop hundreds to thousands of polyps in the large intestine, usually beginning in childhood.
Mutations in the APC gene, when accompanied by increased polyps in the patient and a family history of colon cancer, indicate increased risk of developing familial adenomatous polyposis
(FAP) colon cancer.
The initial use of Aptosyn(TM) is expected to be for the treatment of precancerous colon polyps in patients with familial adenomatous polyposis
Late last year, the FDA approved Celebrex (a COX-2 inhibitor) for treating a rare inherited condition scientists call familial adenomatous polyposis
, in which people develop hundreds of polyps in their colons.
The company is seeking marketing approval of Aptosyn(TM) (exisulind) for the treatment of familial adenomatous polyposis
("FAP"; also known as adenomatous polyposis coli, or "APC"), a rare disease that puts those afflicted at high risk of developing colon cancer.
Investigators discovered APC while studying familial adenomatous polyposis
This report provides information on the therapeutic development for Familial Adenomatous Polyposis
Coli, complete with latest updates, and special features on late-stage and discontinued projects.
Finally, Myriad reported findings from a study, which assessed the polyp history of 1,534 people with mutations in three areas of the APC gene related to attenuated familial adenomatous polyposis
(AFAP) versus mutations elsewhere in the gene.