The spindle cells are negative for S100, EMA, and Factor XIIIa
Clinical significance of measuring blood coagulation factor XIIIA
regularly and continuously in patients with Crohn's disease.
The Factor XIIIA
subunit is encoded by the F13A1 gene.
1) (1997) evaluated 77 oral peripheral nerve sheath tumors using immunohistochemistry to detect the S-100 protein, CD57, epithelial membrane antigen (EMA), factor XIIIa
, CD34, CD68, and collagen IV.
The quantitative measurement of SFC in plasma is complicated by the heterogeneous composition of the analyte as a result of variations in thrombin, factor XIIIa
, and plasmin activity (15,16).
a factor XIIIa
substrate domain) and a bioactive factor (e.
Thomas Huff and Eric Hannappel and their colleagues at the Institute of Biochemistry, University of Erlangen-Nuremberg, Germany reported that TB4 is concentrated at the site of tissue damage through its linkage to an important blood clotting factor, known as factor XIIIa
or transglutaminase, which is released by activated blood platelets.
D, Immunohistochemical staining for factor XIIIa
is typically positive in the histiocytic infiltrate, as is that for CD68 (not shown), but stains for CD1a are negative (not shown) (hematoxylin-eosin, original magnifications x20 [B] and x400 [C]; original magnification x400 [D]).
Alpha-1-antichymotrypsin (1-ACT) & factor XIIIa
Va134Leu polymorphism does not predict risk of coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study.
Immunohistochemically, the spindle cells stain strongly and diffusely for vimentin (7,17) and factor XIIIa
The freshly formed fibrin-rich clot is further stabilized by factor XIIIa
, which cross-links fibrin monomers.
9) The spindle cells characteristically express vimentin, smooth muscle actin, and factor XIIIa
, but some cases may demonstrate desmin, cytokeratin, or anaplastic lymphoma kinase expression.
Unlike schwannomas, neurofibromas are moderately to strongly positive for CD34 and factor XIIIa
, negative or at most focally positive for CD56 and calretinin, and focally positive for neurofilament.