In the two cases, the application of target region sequence capture and next-generation sequencing (NGS) led to the detection of two heterozygous mutations in FLNC
gene: p.D1691N in Case 1 and p.D648Y in Case 2.
Findings demonstrated that FLNC
was expressed in glioma tissues and its level increased as tumour grade advanced.
Valls also managed to offend Corsicans who are not members nor supporters of the FLNC
by first rejecting the acceptance of the Corsican tongue as an official language equal to French (something Corsican nationalists have long agitated for).
Last September, the FLNC
,one of the main Corsican separatist groups, claimed responsibility for a failed attempt to bomb the same Treasury building.
Such attacks by the FLNC
and other militant groups seeking independence from France have been part of life for decades on the Mediterranean island but rare on the French mainland.
Mutations in FLNC
are associated with familial restrictive cardiomyopathy.
[Source:RefSeq mRNA;Acc:NM_001123148] ENSSSCG00000024 694 TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa [Source:HGNC Symbol;Acc:11537] ENSSSCG00000016 409 UBE3C ubiquitin protein ligase E3C [Source:HGNC Symbol;Acc:16803] ENSSSCG00000016 578 FLNC
filamin C, gamma [Source:HGNC Symbol;Acc:3756] ENSSSCG00000012 741 MAMLD 1 mastermind-like domain containing 1 [Source:HGNC Symbol;Acc:2568] ENSSSCG00000012 832 MXRA5 matrix-remodelling associated 5 [Source:HGNC Symbol;Acc:7539] Supplementary Table 4.
In recent years there have been numerous bombings by the Corsican National Liberation Front (FLNC
) but they have mainly targeted holiday homes.