0, which comprises the following targets: Ebola Zaire virus (ZEBOV), Ebola Sudan
virus (SEBOV), MARV, LASV, RVFV, CCHFV, Hantaan virus (HNTV), Seoul virus (SEOV), YFV, and KFDV.
When the researchers exposed the four monkeys vaccinated against Ebola Zaire to another subtype of the virus, called Ebola Sudan
, three of them died, indicating that separate vaccines may be needed against each Ebola subtype.
The initial application of MaxCyte STX and VLX systems will be in fulfillment of a Department of Defense contract for the process development and manufacturing scale-up of VLP-type vaccines against Ebola Zaire, Ebola Sudan
, and Marburg viruses in support of the ongoing preclinical evaluation of the efficacy, potency, and safety of these Filovirus vaccine candidates.
Each species was tallied as to its approximate co-occurrence with distributions (13) of each filovirus (Ebola Ivory Coast in West Africa, Ebola Zaire in central Africa, and Ebola Sudan
and Marburg in East Africa), as well as Ebola Reston, for which we used the entirety of the Philippines, given uncertainty as to the virus's geographic origins.
The researchers will probably next test the vaccine combination against Ebola Sudan
, Nabel says.
Outlier occurrences lie at the eastern extreme of the distribution, consisting of occurrences associated with Ebola Sudan
and Marburg viruses.