Michael's Hospital, also in Toronto, Canada, reanalyzed a pivotal doxylamine
and pyridoxine clinical trial from the 1970s and made a fairly surprising finding: the data had substantial flaws.
Common agents include diphenhydramine, chlorpheniramine, doxylamine
She recommends against using over-the-counter sleep aids containing diphenhydramine or doxylamine
, found in products like Benadryl[R], Nyquil[R] and Unisom[R].
If lifestyle measures aren't enough, you might try an over-the-counter sleep aid that contains the antihistamine diphenhydramine (Nytol, Simply Sleep, some Unisom products and generics) or doxylamine
(Unisom SleepTabs and generic).
Take 25 mg three times a day of vitamin B6 alone or with the antihistamine doxylamine
(after clearing it with your health care professional).
The product is a composition of 10mg doxylamine
succinate and 10mg pyridoxine hydrochloride (vitamin B6) and is indicated for nausea and vomiting during pregnancy when conservative management fails.
Nondiabetic drivers are also exposed to risks from sedating over-the-counter medications sold in convenience stores and gas station mini marts, such as diphenhydramine (Benadryl)--containing products, Tylenol Allergy (acetaminophen with chlorpheniramine), or NyQuil, a cold medicine that contains the antihistamine doxylamine
Over-the-counter sleep aids and medications designed to relieve cold symptoms and allergies contain ingredients such as diphenhydramine (Benadryl), chlorpheniramine, or doxylamine
(Unisom), which can cause severe confusion and lethargy and mimic symptoms of depression.
Over-the-counter medications include antihistamine compounds such as diphenhydramine and doxylamine
Bendectin is a mixture of pyridoxine (Vitamin B6) and doxylamine
(165)--an antihistamine that also has sedative effects and is the sedative ingredient in NyQuil.
Other drugs that can cause false-positive results for some opiate immunoassays include dextromethorphan, diphenhydramine, ephedrine/pseudoephedrine, doxylamine
, chlorpheniramine, brompheniramine, quinolone antibiotics, and rifampin.
The program also proposes various efficacy studies, including pharmokinetic studies of eight ingredients in children aged 2-18 years: phenylephrine, diphenhydramine, pseudoephedrine, chlorpheniramine, brompheniramine, dextromethorphan, guaifenesin, and doxylamine
Mr Heath Ledger died as the result of acute intoxication by the combined effects of oxycodone, hydrocodone, diazepam, temazepam, alprazolam, and doxylamine
," the office said in a statement.
Doctors found oxycodone, hydrocodone, diazepam, temazepam, alprazolam, and doxylamine
in the 28-year-old's system.
Announcing the results of toxicology tests, the New York City medical examiner said: "Mr Heath Ledger died as the result of acute intoxication by the combined effects of oxycodone, hydrocodone, diazepam, temazepam, alprazolam and doxylamine