The actor died as a result of "acute intoxication" by the combined effects of oxycodone, hydrocodone, diazepam, temazepam, alprazolam and doxylamine
, coroner's officials said Wednesday.
There are two in this category, diphenhydramine (such as Benadryl), and doxylamine
(Unisom Nighttime Sleep Aid).
The drug is a combination of the antihistamine doxylamine
and vitamin [B.
Antihistamines such as Diphenhydramine and Doxylamine
are also sedative.
Key Words: diphenhydramine, doxylamine
, histamine [H.
Contains (per tablet): 450mg paracetamol, 10mg codeine phosphate, 5mg doxylamine
succinate, 30mg caffeine
In 2007 and 2008, the Food and Drug Administration (FDA) warned parents of children's OTC medications containing any of the eight specific, active ingredients of concern, including phenylephrine, diphenhydramine, pseudoephedrine, clorpheniramine, brompheniramine, dextromethorphan, guaifensisin, doxylamine
Pyridoxine hydrochloride, doxylamine
succinate enteric coated tablet 10mg / 10mg.
Important Safety Information Do not take Diclegis if you are allergic to doxylamine
succinate, other ethanolamine derivative antihistamines, pyridoxine hydrochloride, or any of the ingredients in Diclegis.
The delayed-release combination of the antihistamine doxylamine
and vitamin [B.
a delayed-release combination of 10 mg doxylamine
and 10 mg pyridoxine) is effective in reducing symptoms of severe NVP in patients at high risk for recurrence of severe NVP.
The most commonly prescribed over-the-counter agent for this condition is doxylamine
(Unisom), usually combined with vitamin [B.
TABLE 5 Other Sleep-Inducing Medications Half-life [*] Drug Hours Days Zolpidem (Ambien) 2 - 3 - Zaleplon (Sonata) 1 - Gabapentin (Neurontin) 5 - 7 - Sedating version tricyclic antidepressants [*] - 1/3 -2 Trazodone (also an antidepressant) (Desyrel) 5 - 9 - Sedating version new generation 1 - 10 antidepressants [+] - - Diphenhydramine (Benadryl) 3 - 12 - Hydroxyzine (Atarax, Vistaril) 3 - Doxylamine
(Unisom) 10 - (*)Half-lives highly variable between specific drugs in this class: eg, doxepine (Sinequam) = 8 hours; amitriptyline (Elavil, Endep) = 1 day; nortirptyline, (Aventyl, Pamelor) = 1 day.
Now, the Canadian team has done the same type of experiment with five common antihistamines: loratadine (Claritin), astemizole (Hismanal), hydroxyzine (Atarax), doxylamine
(Unisom and Nyquil), and cetirizine (Reactine).
Diclectin, a delayed-release combination of doxylamine
and vitamin B[sub.