The agency did not act on the petitions until July 2009, when it required the manufacturer of Darvon
and Darvocet, Xanodyne Pharmaceuticals Inc., to conduct a new safety study of the drug in healthy volunteers.
Xanodyne Pharmaceuticals Inc., the drug's owner since 2005, will withdraw both Darvon
and Darvocet, a product that combines Darvon
's active ingredient with acetaminophen, Food and Drug Administration officials said.
* Pain medications: Certain pain medications, such as morphine, codeine, Percocet, Darvon
, Demerol and OxyContin, can cause symptoms of depression while in use, and upon withdrawal.
The most commonly prescribed, and the most commonly abused by teens, are OxyContin, Darvon
, Vicodin, Percocet, Percodan, and Tylenol with Codeine.
Examples of opioids include morphine, codeine, methadone, Demerol, and Darvon
Of those who used pain relievers, 48% used Vicodin, Lortab, or Lorcet; 34% used Darvocet, Darvon
, or Tylenol with codeine; and 20% used Percocet, Percodan, or Tylox.
TABLE Potentially inappropriate medications in the elderly MEDICATION POTENTIAL ADVERSE EFFECT Meperidine (Demerol) Confusion Propoxyphene (Darvon
) CNS effects Diphenhydramine (Benadryl) Sedation Long-term use of NSAIDs GI bleeding Amitriptyline (Elavil) Sedation/anticholinergic effects Methyldopa (Aldomet) Bradycardia Diazepam (Valium) Sedation Cimetidine (Tagamet) Confusion Nitrofurantoin (Macrodantin) Potential renal insufficiency Clonidine (Catapres) Hypotension/CNS effects Disopyramide (Norpace) Heart failure Ketorolac (Toradol) GI bleeding Short-acting nifedipine (Procardia) Hypotension Doxazosin (Cardura) Hypotension
Low-dose opiates and combinations such as hydrocodone plus acetaminophen (Vicodin, Norco, and others) and propoxyphene (Darvon
) are another option.
The Enzyme Multiplied Immunoassay Test screens for 10 drugs: amphetamines, barbiturates (e.g., Phenobarbital), benzodiazepines, marijuana, metabolite (crack and powder) cocaine, methadone, methaqualone, opiates, phencyclidine (PCP), and propoxyphene (Darvon
Pupils that remain very small, or pinpoint, might suggest that a person is abusing methadone, opiates (such as heroin), codeine, morphine, or propoxyphene (Darvon
Examples include benzodiazepines, darvon
, and phenobarbital.
A 2001 government survey found that close to 3 million kids between 12 and 17 had used prescription drugs, such as Darvon
, Demerol, OxyContin, Percodan and Vicodin, for "fun." And girls are more likely to indulge in this foolish "fun" than guys.
A proponent of the school of thought that, as she put it, "sequins save lives," Diana fulfilled our populist insistence that celebrities fraternize with less fortunate members of society by dandling legless children in mine-strewn Third-World nations and appearing like a celestial vision at the bedside of gay men addled by morphine and Darvon
. "I still remember," one AIDS victim recalls, "how clear her eyes were and how beautiful and shiny her necklace." Her international display of kindness and modesty raked in millions and lingers on in our memories inspiring charitable donations years after her death, posthumous tributes that led one philanthropist to refer to her as "the gift that keeps on giving."
People addicted to pharmaceutical opiates, such as Vicodin, Oxycontin, Darvon
, Percocet and other prescription painkillers, would be candidates for the new drug, he said.