In vivo effect of Daonil on erythrocyte NADH diaphorase activity of rat at pH 8.0 and 30[degrees]C NADH (iu/L) Daonil (mg/200g Day 1 Day 2 body weight) X [+ or -] SD X [+ or -] SD 0.00 6.13 (a) 6.19 [+ or -] 1.24 [+ or -] 0.81 0.01 6.66 (a) 7.83 (b) [+ or -] 0.83 [+ or -] 0.59 0.02 7.00 (b) 8.50 (c) [+ or -] 0.02 [+ or -] 0.01 0.03 7.43 (b) 9.41 (d) [+ or -] 0.01 [+ or -] 0.14 Daonil (mg/200g Day 6 Day 14 body weight) X [+ or -] SD X [+ or -] SD 0.00 6.70 (a) 6.91 (b) [+ or -] 0.65 [+ or -] 0.42 0.01 10.17 (e) 10.35 (e) [+ or -] 0.69 [+ or -] 0.96 0.02 10.35 (e) 11.01 (f) [+ or -] 0.97 [+ or -] 1.41 0.03 11.44 (f) 7.04 (b) [+ or -] 0.82 [+ or -] 1.03 Table 2.
The activation of the enzyme by daonil and glucophage confirms the work of Chasseaud (1979) in which he proposed that erythrocyte enzyme functions to detoxify red cell xenobiotics.
In addition, In vivo studies of the products of glibenclamide tablets indicated that there is no significant difference in percent reduction of blood glucose level between Daonil and the other brands (p > 0.05).
Statistical analysis was conducted using Dunnett's t-test and it was found that, at 95% confidence interval, there was no significant difference in the percent reduction of blood glucose level between Daonil and Glitisol, between Daonil and Melix, and between Daonil and Betanase at l h (p >0.05), while Glamide was significantly different from the innovator product.
Those, who are on sulfonylureas (daonil
, glimipride, glyclazide) and insulin have the risk of hypoglycemia on fasting.
This results confirmed the objectives of the research in that Balanites aegyptiaca pure saponin had a significant impact on the control of type II Diabetes mellitus compared with Daonil and on the inhibition of Escherichia coli growth in rats.
The fourth and the fifth were given Daonil (as a standard medication) and water.
Hoechst fought back with an advertising campaign warning patients about a fake of its diabetes drug Daonil
. There was no panic and there were no lost sales.