Studies have demonstrated efficient transplacental transfer of anti-pertussis antibodies to the fetus, which protects the infant until they are old enough to receive the first dose of DTP vaccine
at two months.
In 1984, for example, Lederle's President went on record declaring that "[t]he present dollar demand of DTP lawsuits against Lederle is 200 times greater than our total sales of DTP vaccine
in 1983." (120) Then, the following year, he complained the situation had deteriorated: "All but two of the more than ninety" DTP cases filed against Lederle--in more than forty years of distributing the vaccine--had been filed since 1982.
Two-thirds of a group of 4138 children born between 1987 and 1989 in 45 adjacent villages in western India received their BCG and DTP vaccines
out of sequence, receiving either both vaccinations at the same time or the BCG after the DTP.
Among the children worldwide who did not receive 3 doses of DTP vaccine
during the first year of life in 2009 approximately half live in India (37%) and Nigeria (14%).
The first whole cell Bordetella vaccine was developed in the 1930s and was in widespread used by the mild 1940 when Pertussis vaccine combined with Diphtheria Toxoid and Tetanus Toxoid to make the combination DTP vaccine
. In 1991, DTP vaccine
was licensed in the United States.
and chronic nervous system dysfunction: a new analysis.
Of the children with records of DTP vaccine
, 99% were titer positive for diphtheria antibody and 88% were titer positive for tetanus.
The UK primary vaccine schedule consisted of 3 doses of Hib conjugate vaccine, DTP vaccine
, oral polio vaccine, and MCC vaccine all administered at 2, 3, and 4 months of age.
adolescents have not received at least one of the vaccines recommended for them (hepatitis B, MMR, varicella, meningococcal, or the combination DTP vaccine
GSK plans to conduct clinical R&D for four products in India in 2005--two vaccines for rotavirus, one for cervical cancer, and a combination DTP vaccine
Contrary to the expectation, the researchers, writing in the journal Paediatrics, said the figures appeared to show that the earlier the child was immunised with the DTP vaccine
, the fewer the problems reported as they got older.
In the 1970s, to allay public fears about the whooping cough element of the combined DTP vaccine
, the jabs were offered separately.
Allegations of other serious adverse reactions, such as permanent neurologic damage, after a dose of DTP vaccine
are controversial and have been discussed elsewhere in depth.
In 1985, makers of the DTP vaccine
were facing $4 billion in claims filed in US courts.
The vaccine is now mixed with the DTP vaccine
and given in one injection.