Further, patients with cystinuria who are intolerant of D-penicillamine
may need to be switched to tiopronin (Pearle et al., 2014), and patients with APRT deficiency who cannot tolerate allopurinol may benefit from febuxostat therapy.
Effect of D-penicillamine
on liver fibrosis and inflammation in Wilson disease.
, zinc, triethylenetetramine and amonnium tetratiomolibdate are used in treatment of WD.
Copper chelation by D-penicillamine
generates reactive oxygen species that are cytotoxic to human leukemia and breast cancer cells.
In a study in which wound contraction was treated with local injections of BAPN and D-penicillamine
, Joseph et al.
The patient recovered after chelation therapy with D-penicillamine
Although most studies report no association with certain drugs, (4,5) rare case reports have implicated interleukin 4 and D-penicillamine
in precipitating Grover disease.
In 2002, Kaya et al reported a case in which D-penicillamine
at 600 mg/day produced a modest clinical benefit and relieved symptoms for a period of time.
(D-P) is a chelator drug which is used for treatment of lead toxicity for several years.
Method: A 24-hour urine test during a short noninvasive provocation using oral d-penicillamine
[Cupramine[TM], D-Pen[TM] dimethylcysteine, mercaptovaline] or Acetyl-penicillamine, prescribed by a physician.
She began a course of copper chelation with D-penicillamine
, and she awaits liver transplantation.
. Although no longer used routinely in rheumatology, D-penicillamine
has been used for Wilson's disease, scleroderma, rheumatoid arthritis, and cystinuria.
These drugs include methotrexate, hydroxychloroquine, sulfasalzine, corticosteroids, intramuscular and oral gold, d-penicillamine
, minocycline, azathioprine, cyclosporine, leflunomide, and etanercept.
It also can be associated with malignancy, D-penicillamine
therapy, nephrotic syndrome, hypothyroidism, and AIDS.
Drugs used to treat rheumatoid arthritis include gold by injection and mouth, D-penicillamine
, sulphasalazine, methotrexate, asathioprine, cyclophosphamide, cyclosporin-Aand anti-malarial drugs.