"Globally, one baby out of every 1,000 is born deaf, with hearing loss commonly associated with genetic predispositions, complications during birth, or diseases such as rubella, the cytomegalo
virus or herpes.
Class Diseases Prevention Class1 Measles, mumps, rubella, Vaccines available Risk tetanus, diphlheria, minimal polioniyeitis, influenza, fungal infecton Class 2 Gonoirhofla, syphiis, No vaccines But treatment granutoma inguinale, is available Risk more lympho granuloma venerum, than class 1 candidiasis, staphylococcus aureus, pp A streptococcus Class 3 Varicella, hep simplex, High rate of cytomegalo
virus, EBV prevalence Troublesome clinically Class 4 HBV, HCV, HDV, HIV No vaccine, except HBV, Disease fatal Universal precaution should be taken Class 5 TB Vaccine not 100% effective Air home transmission Highest risk Respiratory precautions Infection control:
At the next steps of this project, we are going to evaluate the expression efficiency of this codon- optimized gene which is currently under the human cytomegalo
virus (hCMV) promoter, through pIRES- EGFP vector, in the chicken embryo fibroblast cells.
of patients Abortion 38 Intrauterine growth retardation 21 Intrauterine death 09 Preterm labour 07 Early neonatal death 20 Congenital malformation 05 Total 100 Table 3 - Seropositivity of each infection agent within TORCH test Seropositivity Seropositivity HDRF (n=100) Controls (n=5) TORCH agent Number % Number % Toxoplasma 41 41 07 14 Rubella 18 18 02 04 Cytomegalo
27 27 03 06 virus(CMV) Herpes Simplex 14 14 02 04 Virus(HSV) Total 100 100 14 28 Table 4 - TORCH agents with different presentations of HDRF cases.