Basaloid squamous cell carcinoma (A, hematoxylin-eosin) lacks diffuse staining for BerEp4 (B), cytokeratin
14 (C), and cytokeratin
17 (D) immunohistochemical stains, original magnifications X100 [A].
To confirm that they got the right protein, the researchers used gene-silencing techniques to reduce the expression of cytokeratin
6A in the cornea of mice.
In the study, the lymph nodes were sectioned according to previously mentioned standards, with a TI cytology prepared and two sections--one FS and one slide prepared with the rapid cytokeratin
Sustentacular cells were positive for S-100 protein (Figure 2C), but negative for high molecular cytokeratins
, monoclonal CEA.
We used the MetaMorph Imaging System to measure the area of alveolar tissue labeled by fluorochromes indicating expression of Bax (red), CYP1A1 (blue), and cytokeratin
Desmoglein 3 + cytokeratin
5/napsin A cocktail immunostain; napsin A (red) displaying variable staining intensity in well differentiated (A) and moderately differentiated (B) and weak staining in poorly differentiated (C) adenocarcinoma.
Nonspecific intermediate filaments were present but no cytokeratin
filaments or myofilaments.
On immunohistochemistry tumour cells exhibit strong diffuse positivity with smooth muscle actin, and are negative for cytokeratin
and S100 (Z).
Sinonasal undifferentiated carcinoma, nasopharyngeal-type undifferentiated carcinoma, and keratinizing and nonkeratinizing squamous cell carcinoma express different cytokeratin
positive results for thyroglobulin and thyroid transcription factor-1; a distinctive cell-membrane staining pattern for MIB-1; negative results for calcitonin and HBME-1; and either positive or negative results for cytokeratin
19, which is strongly and diffusely positive in papillary carcinoma (2, 3).
Monoclonal antibodies against proliferating cell nuclear antigen (PCNA, 610664), cytokeratin
5/8 (550505), and plasminogen activator inhibitor-1 (PAI-1, 612024) were purchased from BD Biosciences (San Jose, CA).
Immunohistochemistry demonstrated positivity for cytokeratin
AE1/AE3 only in the conventional adenocarcinoma component.
Reverse transcription-PCR (RT-PCR) for cytokeratin
19 (CK19) may be a useful alternative or complement to immunocytochemical detection (2).
The papillary mass' immunophenotypic expression had positive vimentin and cytokeratin
7--we concluded he had papillary RCC (Fig.
Anti-CK 8/18 is the first rabbit monoclonal antibody cocktail for cytokeratin
8/18 (CK 8/18) available from a major pathology provider.