Niedobitek, "Activation-induced cytidine deaminase
(AID) is expressed in normal spermatogenesis but only infrequently in testicular germ cell tumours," Journal of Pathology, vol.
Through a series of steps, the enzyme cytidine deaminase
bolted to dead Cas9 converts a C-G DNA base pair into T-A base pair.
Deoxycytidine kinase is the rate-limiting enzyme for gemcitabine activation and cytidine deaminase
inactivates gemcitabine to difluorodeoxyuridine, allowing the metabolite to be cleared from the cell .
The upregulation of Bcl-6 in activated GC B cells supports their survival and extremely high proliferation rate and additionally leads to the activation-induced cytidine deaminase
(AID) mediated somatic hypermutation (SHM) in the dark zone of GCs .
Curcumin further inhibits Helicobacter pylori mediated carcinogenesis in gastric tissue by down regulating H pylori induced expression of activation-induced cytidine deaminase
(Zaidi et al.
The authors have demonstrated an increase of intratumoral gemcitabine levels attributable to a marked decrease in the primary gemcitabine metabolizing enzyme, cytidine deaminase
. Correspondingly, paclitaxel reduced the levels of cytidine deaminase
protein in cultured cells through reactive oxygen species-mediated degradation, resulting in the increased stabilization of gemcitabine.
Drug inactivation can result from Ara-CMP conversion into Ara-uracil by cytidine deaminase
(cdd), or from dephosphorylation of Ara-CMP by cytoplasmic nucleotidase (3).
1 HIGM is characterized by reduced serum levels of IgG and IgA and normal or elevated IgM level, resulting from mutations in different genes including CD40 ligand, CD40, activation induced cytidine deaminase
(AID), and Uracil g (UNG).
Activation-induced cytidine deaminase
(AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).
This protein is a cellular cytidine deaminase
that is encapsulated into assembling virions in the absence of vif and is inhibitory during the next round of viral replication.