Through a series of steps, the enzyme cytidine deaminase
bolted to dead Cas9 converts a C-G DNA base pair into T-A base pair.
Early severe toxicities after capecitabine intake: possible implication of a cytidine deaminase
extensive metabolizer profile.
Chemoresistance to Ara-C can arise from a number of factors influencing the rate of Ara-CTP formation and incorporation into DNA (5), including low drug uptake, conversion into Ara-uracil by cytidine deaminase
, or dephosphorylation of active metabolite by cytoplasmic nucleotidase (6).
1 HIGM is characterized by reduced serum levels of IgG and IgA and normal or elevated IgM level, resulting from mutations in different genes including CD40 ligand, CD40, activation induced cytidine deaminase
(AID), and Uracil g (UNG).
Activation-induced cytidine deaminase
(AID), a protein necessary for somatic hypermutation and class switch recombination, is expressed in the germinal center (10) and in extrafollicular large proliferating B cells.
This protein is a cellular cytidine deaminase
that is encapsulated into assembling virions in the absence of vif and is inhibitory during the next round of viral replication.
Curcumin further inhibits Helicobacter pylori mediated carcinogenesis in gastric tissue by down regulating H pylori induced expression of activation-induced cytidine deaminase
(Zaidi et al.
The study of Robbiani et al  demonstrated an association between DNA damage response pathways and the development of B-cell lymphoma in cells over-expressing activation-induced cytidine deaminase