The cyclic nucleotide
PDEs, which hydrolyze cyclic AMP and cyclic GMP, play a pivotal role in intracellular signaling cascades (Lugnier, 2006).
Effects of phosphodiesterase inhibitors on tension induced by norepinephrine and accumulation of cyclic nucleotides
in iso- lated human prostatic tissue.
Oscillating cycles of second messengers, including calcium and cyclic nucleotides
, entrain biological clocks in systems as diverse as plants (Johnson et at.
The reduced platelet antiaggregatory activity exerted by both cyclic nucleotides
(11) does not necessarily lead to impaired activation of cyclic nucleotide
/specific kinase/ VASP pathways.
The stimulation of bovine epididymal sperm metabolism by cyclic nucleotide
Objective: "This project aims to unite global efforts to target the highly druggable class of enzymes called cyclic nucleotide
phosphodiesterases (PDEs) in the fight for neglected parasitic diseases (NPD).
Leavesley, "Perspectives on: Cyclic nucleotide
microdomains and signaling specificity: Can we decipher the information content contained within cyclic nucleotide
In cyclic nucleotide
assays, baicalin enhanced both cAMP and cGMP levels in MAs.
response element binding (CREB) protein activation is involved in K562 erythroleukemia cells differentiation.
Where PDE5 breaks down cyclic nucleotides
in response to the vital signaling molecule nitric oxide (NO), PDE1 affects cyclic nucleotide
pathways sensitive to Calcium (Ca2+), another major player in cardiac disease, according to the authors.
In presenting these conceptual and technical approaches to cyclic nucleotide
phosphodiesterases (PDEs), Lugnier (pharmacology and the physico-chemistry of cellular and molecular interactions, Centre National de la Recherche Scientifique, U.
A cyclic nucleotide
dispensation approach with iterative addition of the nucleotides as well as a programmed approach was evaluated.
Cyclic AMP (cAMP) is an important second messenger that activates protein kinase A (PKA), cyclic nucleotide
gated (CNG) channels, and exchange protein activated by cAMP (Epac) and regulates cellular and physiological functions.
In the previous study, Insel's group had discovered that among a group of enzymes, cyclic nucleotide
phosphodiesterases, one of the phosphodiesterases, PDE7B, was 10 times higher in CLL patients than in healthy individuals.
second messengers clearly play a role in mediating pigment translocation in crustacean chromatophores (Fingerman, 1969; Rao and Fingerman, 1983; Nery et al.