Role of cyclic adenosine monophosphate
pathway in the mRNA gene expression of IL-6
Cyclic adenosine monophosphate
response element-binding protein (CREB) is a cellular transcription factor that binds to certain DNA sequences called cyclic adenosine monophosphate
response elements and influences transcription of downstream genes.
Further study demonstrated that S[O.sub.2] elevated cellular cyclic adenosine monophosphate
(cAMP) production to activate the PKA signaling, subsequently phosphorylated c-Raf on Ser259 site to block its activation, and then inhibited the extracellular regulated protein kinase (Erk)/mitogen-activated protein kinase (MAPK) signaling transduction, which finally prevented cell cycle progression and led to the suppression ofVSMC proliferation .
Experiments with cultured human cells also showed that caffeine competitively bound to adenosine receptors, which disrupted signaling of cyclic adenosine monophosphate
(cAMP), a key part of the circadian clock, the researchers said.
Elevation of the second messenger cyclic adenosine monophosphate
(cAMP) in macrophages suppresses several inflammatory responses, including inflammatory mediator production and receptor-mediated phagocytosis.
Otezla is an oral small-molecule inhibitor of phosphodiesterase 4 (PDE4) specific for cyclic adenosine monophosphate
Bauer, "Microparticles from pulmonary microvascular endothelial cells contain cyclic adenosine monophosphate
OTEZLA (apremilast) is an oral, small-molecule inhibitor of phosphodiesterase 4 (PDE4) specific for cyclic adenosine monophosphate