Mohan et al., "Phytomedicine Cardioprotective properties of Crataegus oxycantha
extract against ischemia-reperfusion injury," Phytomedicine, vol.
(2009) researched that vasodilatory potential of the wild strawberry leaves aqueous extract was compared with vasodilatory activity of aqueous extract of hawthorn (Crataegus oxycantha
L.) leaves with flowers, which can be regarded as a reference plant extract with a marked vasodilatory activity.
The study showed that an ethanolic extract of Crataegus oxycantha
can act as an antioxidant and activator of intracellular signalling, which can protect the myocardium during reperfusion.
Aaronson, "The effect of Crataegus oxycantha
special extract WS 1442 on clinical progression in patients with mild to moderate symptoms of heart failure," European Journal of Heart Failure, vol.
b) The administration of Crataegus oxycantha improved cardiac contractility and left ventricular function.
c) Crataegus oxycantha extract has antioxidant activity in human hearts.
d) Crataegus oxycantha treatment significantly increased the activity of CK and LDH.
The latest research proves that Crataegus oxycantha
extract, which is aboundant in proanthocyanidins, reduce the oxidative stress and exert cardioprotective effect in the reperfused myocardium by inhibition of apoptotic pathways (Swaminathan et al.
The ethanolic extract of Crataegus oxycantha (COC) is traditionally used as a cardiotonic in China, India, and many European countries.
Protective effect of Crataegus oxycantha against reperfusion arrhythmias after global no-flow ischemia in the rat heart.
Abbreviations: COC, Crataegus oxycantha; I/R, Ischemia/reperfusion; OPC, Oligomeric proanthocyanidin; ROS, Reactive oxygen species; LVDP, Left ventricular developed pressure; CF, Coronary flow; HR, Heart rate; RPP, Rate pressure product; LDH, Lactate dehydrogenase; CK, Creatine kinase; TTC, Triphenyltetrazolium chloride
Vasodilatory potential of the wild strawberry leaves extract was compared with vasodilatory activity of aqueous extract of hawthorn (Crataegus oxycantha, L) leaves with flowers, which can be regarded as a reference plant extract with a marked vasodilatory activity.
Keywords: Fragaria vesca L.; Crataegus oxycantha L.; Wild strawberry leaves; Aqueous extract; Vasodilation; Phenolics
leaves (produced and distributed by Suban, Samobor, Croatia) and Crataegus oxycantha L.
Extracts of hawthorn (Crataegus oxycantha
) have become popular herbal supplements for their well-recognized cardiotonic effects.