The liver enzyme, total and conjugated bilirubin
, and histology results of the liver biopsies and abdominal ultrasonography, were tabulated.
Some infants, on the other hand, have high conjugated bilirubin
Surprisingly, we found that conjugated bilirubin
slightly prolonged aPTT in citrated plasma, and more prominent prolongation was observed in heparinized samples.
is gold in colour and when mixed with bile is responsible for the colouration of stools and urine (England, 2010).
Direct bilirubin is a measure of the amount of conjugated bilirubin
, and is determined directly.
Because conjugated bilirubin
does not cross the placenta from the fetal into the maternal circulation, it is excreted into the fetal bile or amniotic fluid, where it is then transferred to the maternal circulation.
The term cholestasis refers to a group of disorders associated with bilirubin excretion and accompanied by a rise in serum conjugated bilirubin
levels and often, bile salts and phospholipids.
A conjugated bilirubin
of greater than 20% of total bilirubin was considered to be abnormal.
Laboratory investigations revealed evidence of obstructive jaundice with serum total bilirubin of 16 mg/dL and conjugated bilirubin
Markedly greater elevations of unconjugated bilirubin relative to elevations of conjugated bilirubin
in the blood suggest hemolysis (destruction of red blood cells).
The addition of glucuronide makes conjugated bilirubin
water soluble and capable of canalicular transport into the bile.
He also had an elevated total bilirubin of 62 [micro]mol/l (normal=2-26 [micro]mol/l) and elevated conjugated bilirubin
of 11 [micro]mol/l (normal=1-7 [micro]mol/l).
Indeed, most parents and health care providers do not seek further investigation for infants with prolonged jaundice, despite the recommendations of the Canadian Pediatric Society (CPS) that infants who are jaundiced beyond two weeks of age should have a measurement of total and conjugated bilirubin
Liver function tests confirmed an obstructive jaundice (total bilirubin 122 [micro]mol/l , conjugated bilirubin
76 [micro]mol/l, gamma-glutamyl tranferase 394 U/l, and alkaline phosphatase 670 U/l).
Indirect bilirubin levels measure "free" or unconjugated bilirubin and direct bilirubin levels measure conjugated bilirubin
(Pagana & Pagana, 2002).