Because of concerns of increased sedation, intranasal esketamine should be administered cautiously in patients receiving other CNS depressants
, such as benzodiazepines.
Barbiturates are general CNS depressants
that induce a state of calm, sedation, and hypnosis at high doses .
"Our research has identified many CNS depressants
which could be associated with symptoms such as dizziness, incoordination, nausea, unconsciousness, fatigue, drowsiness, tension and sweating which have been reported among smokers of dokha and shisha," said Dr Yehya Al Sayed, Associate Professor in Biology, Chemistry and Environmental Sciences at AUS.
Centrally acting drugs - antihistamines, sedatives tranquilizers, and parasympathetic and CNS depressants
- offer only a short term solution, especially for some severe cases.10 For the more severe cases, other complicated techniques have been used.
"We implore health care professionals to heed these new warnings and more carefully and thoroughly evaluate, on a patient-by-patient basis, whether the benefits of using opioids and benzodiazepines--or CNS depressants
more generally--together outweigh these serious risks."
Typically it is opioids, CNS depressants
and stimulants that are the three most established chug classes that are abused.
, such as sedatives and anesthetics, are incredibly important in human and animal health (8,9).
Flibanserin also should not be prescribed for patients who use other CNS depressants
such as diphenhydramine, opioids, benzodiazepines, and hypnotic agents.