DISCUSSION: Imatinib mesylate inhibits bcr-abl tyrosine kinase, Tyrosine kinase enzyme is regarded as the cause of Philadelphia chromosome--positive Chronic Myelogenous leukemia
(CML), Gastrointestinal stromal tumors (GIST) (1-2) and other rare neoplasms (Dermatofibrosarcoma Protuberans) Imatinib (3-5) is used for treatment of CML in:
A case of chronic myelogenous leukemia
associated with operated gastric cancer.
Characteristics of Chronic Myelogenous Leukemia
Chronic Phase * Peripheral blood leucocytosis is reflected in numerical increase in all stages of myeloid differentiation.
It was approved in June 2006 for the treatment of adults with chronic-phase, acute-phase, or myeloid or lymphoid blast-phase chronic myelogenous leukemia
(CML) with resistance or intolerance to prior therapy, including imatinib, and for the treatment of adults with Philadelphia chromosome-positive (Ph+) acute lymphocytic leukemia (ALL) with resistance to prior therapy.
Since its introduction a few years ago, the cancer drug imatinib has given patients with chronic myelogenous leukemia
an unprecedented chance at long-term survival.
San Diego, CA) announced that it has entered into a license and collaboration agreement with Novartis focused on the development and commercialization of BCR-ABL inhibitors for the treatment of drug resistant Chronic Myelogenous Leukemia
NS-187, which is a molecular targeted agent in the preclinical stage, is intended for the treatment of chronic myelogenous leukemia
1 -- color) Virginia Garner of Claremont was diagnosed with chronic myelogenous leukemia
eight years ago, but has been helped with doses of the drug Gleevec.
In the 18th and 19th centuries, Fowler's solution (containing 1% arsenic trioxide) was prescribed to treat asthma, psoriasis, syphilis, and chronic myelogenous leukemia
(Waxman and Anderson 2001).
Busulfex was approved for marketing in the US in 1999 for use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous leukemia
Then came the determination that I had developed chronic myelogenous leukemia
The model that melanoma researchers are holding high for inspiration is that of another malignancy where a single recurrent genetic mutation figures prominently: chronic myelogenous leukemia
Redmond's father, actor Ryan O'Neal - who is suffering from chronic myelogenous leukemia
- pulled him out of a drug clinic in Mexico at Christmas then sent him back to his mother in April.
Graft-versus-host disease of the skin, liver, and digestive tract developed in a 39-year-old woman with chronic myelogenous leukemia
after an allogeneic hematopoietic stem cell transplant in September 1995, during which she was treated with cyclosporine and high-dose prednisolone.
Rapidly progressive pulmonary infiltrates in chronic myelogenous leukemia