* Acute cholinergic
crisis--within 24 hours after the initial presentation, and described in patient 4.
Combinations of memantine and cholinergic
drugs have been found to have a synergistic effect that is especially helpful in treating AD.
Combinations of memantine with cholinergic
drugs have been found to be efficacious in AD, since the treatments have synergistic mechanisms of action.
[sup] Certain calcium-mobilizing contractile agonists, particularly muscarinic cholinergic
agonists (e.g., acetylcholine [Ach]), directly inhibit adenylyl cyclase activity.
"There is evidence from our studies and from other, smaller studies that behavioral symptoms can improve with cholinergic
treatment," said Dr.
Botulinum toxin binds with high affinity to cholinergic
nerve endings, including the motor and autonomic nerves.