The AMP is one of the choline antagonists which have been demonstrated to slow down the choline biosynthesis through the inhibition of S-adenosyl-methionine-dependent methylation and results in choline deficiency
Genetic Variation of Folate-Mediated One-Carbon Transfer Pathway Predicts Susceptibility to Choline Deficiency
in Humans" (2005) 102 Proceedings of the National Academy of Sciences of the United States of America 16025.
Previous research has shown that choline deficiency
causes fatty liver and other liver damage.
The pathways were altered by feeding either methionine or homocystine (H-H) in conjunction with either folic acid (FA) or choline deficiency
With this method, the effects of folate deficiency (6), chronic choline deficiency
(7), alcohol intake (8), and choline deficiency
and methotrexate treatment (5) on folate form distribution in several tissues in rats have been examined.
June 9, 2015 /PRNewswire/ -- Recent research clarifies the relationship between choline deficiency
and nonalcoholic fatty liver disease (NAFLD), and provides details about how choline affects liver health.
However, the fad might have become popularized because of a pervasive choline deficiency
in our population.
was also associated with elevated blood homocysteine levels.
a biotechnology company, today announced it has entered into a research collaboration with the University of North Carolina at Chapel Hill to identify biomarkers indicative of choline deficiency
, a physiological state that has been implicated in the onset of liver damage in humans.