Variation in epitopes of the B subunit of Vibrio cholerae non-O1 and Vibrio mimicus cholera toxins
The UC San Diego researchers found that cholera toxin
acts by two entirely distinct, but cooperating mechanisms to produce diarrhea.
Distribution of serogroups of Vibrio cholerae non-O1 non-O139 with specific reference to their ability to produce cholera toxin
, and addition of novel serogroups.
The animals getting the vaccine fended off a subsequent oral dose of full-strength cholera toxin
, while mice that had received regular rice powder experienced severe diarrhea, the researchers report in an upcoming Proceedings of the National Academy of Sciences.
When the magnetic nanoparticles are added to water, blood, or other fluids to be tested, the cholera toxin
binds to the nanoparticles in a way that can be easily detected by instruments.
cholerae clearly showing that the exotoxin nature of cholera toxin
And the cholera toxin
is being tested in the prevention of arthritis and other auto-immune diseases.
One of the adjuvant approaches exploits the enzymatically active A1 subunit of cholera toxin
(CTA1), which can be expressed from DNA, RNA, and viral vectors.
Changing genotypes of cholera toxin
(CT) of Vibrio cholerae O139 in Bangladesh and description of three new CT genotypes.
The technology allows for the expression and secretion of an antigen genetically coupled to the non-toxic B subunit of cholera toxin
to enhance immunogenicity.
Vibrio cholerae cytolysin is essential for high enterotoxicity and apoptosis induction produced by a cholera toxin
The technique would allow relief workers to test water sources that could be contaminated with the cholera toxin
The final chapter, on the involvement of protein structure in medicine, gives as examples sickle cell anemia, HIV, cholera toxin
action, influenza, the p53 proteins in relation to malignancy, antitrypsin deficiency, and the role of protein misfolding in neurodegenerative diseases.
This deadly disease is attributed to infections by Vibrio cholera, but it's actually bacteriophages genes inside the bacterium that carry the instructions for cholera toxin
(SN: 6/29/96, p.
Poster # P21: Title: "The A1 Subunit of Cholera Toxin
as an Adjuvant for DNA Vaccines"