This technology can enable successful clinical translation of promising chemotherapeutics
whose success would otherwise be prevented due to poor aqueous solubility and reliance on toxic excipients.
The company introduced its PDC platform for the targeted delivery of chemotherapeutics
during its second quarter financial results call in August 2015.
Citation: "Systematic screen of chemotherapeutics
in Drosophila stem cell tumors"; Michele Markstein et al.
One mechanism by which this opposition, commonly known as chemoresistance, happens is through the expression of drug transporter pumps in leukemia cells that actively pump out chemotherapeutics
, including Daunorubicin.
The major advance here is that we were able make biodegradable nanoparticles that can rapidly penetrate thick and sticky mucus secretions, and that these particles can transport a wide range of therapeutic molecules, from small molecules such as chemotherapeutics
and steroids to macromolecules such as proteins and nucleic acids," Hanes said.
Some of the nation's brightest leaders of tomorrow took on groundbreaking research regarding life-threatening infections and the deadly side effects of chemotherapeutics
Genomic signatures to guide the use of chemotherapeutics
In those studies, 87% of women treated with Herceptin plus the other chemotherapeutics
were disease free after 3.
The drug fits well into our product portfolio, which already contains medicine against adverse effects of chemotherapeutics
Traditional pharmaceuticals consist of the following types: small molecules, which are organic compounds that interact with biological functioning, such as aspirin or chemotherapeutics
(materials toxic to tumor cells); natural products, such as antibiotics, which are products of molds, fungus or bacteria; and biologics, which are materials extracted from organisms, such as insulin.
Chemosensitizers are now being tested in clinical trials to prevent tumor cells from resisting harsh chemotherapeutics
8,9) Additionally, in contrast to local chemotherapeutics
, systemic antibiotic usage presents the risk of producing antibiotic resistant bacterial strains.
have traditionally dominated the cancer treatment field, but they often have been associated with serious side effects and drug resistance.
The company says standard and recently approved chemotherapeutics
for non-transplant regimens for multiple myeloma generally provide complete response rates of less than 5%.
Through vigorous efforts made in the past two centuries, public health workers have succeeded in developing vaccines, antibiotics, and chemotherapeutics
, and as a result most infectious diseases have been brought under control in industrialized countries.